Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

Background/AimsAn impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified albumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI).MethodsForty patients with CRC (19 females and 21 males; mean age, 56.5±2.1 years) and 39 age- and sex-matched healthy people (22 females and 17 males; mean age, 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated.ResultsSerum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32).ConclusionsIn this study, the oxidative/antioxidant status was impaired in favor of oxidative stress in CRC patients. This observation was not confirmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers.

Objective:The two-step approach recommended by the National Diabetes Data Group (NDDG), Carpenter and Coustan (C&C), and O’Sullivan, and the single-step approach recommended by the International Association of Diabetes and Pregnancy Study Group (IADPSG) are used to diagnose gestational diabetes mellitus (GDM). We aimed to determine GDM prevalence and to compare the two-step and single-step approaches used in the southeastern region of Turkey.Materials and Methods:In total, 3048 records of pregnant women screened for GDM between 2008 and 2014 were retrospectively extracted from our laboratory information system. GDM was defined according to the criteria of NDDG, C&C, and O’Sullivan between in 2008 and 2011, and according to those of the IADPSG between 2012 and 2014. Demographic variables were compared using student’s t-test. The linear trends in GDM prevalence with age were calculated using logistic regression.Results:GDM prevalence was found as 4.8%, 8%, and 13.4% using the NDDG, C&C, and O’Sullivan two-step approach, respectively, and 22.3% with the IADPSG single-step approach. GDM prevalence increased with increasing age in both approaches.Conclusion:GDM prevalence was higher using the single-step approach than with the two-step approach. There was a significant increase in GDM prevalence using the IADPSG criteria.

ÖzetAmaç: Akut koroner sendrom, akut göğüs ağrısı ve miyokard iskemisine bağ-lı gelişen semptomları içeren klinik bir durumdur. İskemi modifiye albumin (IMA) son yıllarda AKS tanısında kullanılmaya başlanan yeni bir belirteçtir. İs-kemi durumunda oluşan reaktif oksijen radikallerinin IMA oluşumuna neden olduğu saptanmıştır. Bizim çalışmamızın amacı, yeni bir kardiyak iskemi belirteci olan IMA'nın AKS'deki düzeylerini tespit etmek ve reaktif oksijen radikali oluşumuna neden olan sigara içiminin IMA düzeylerine etkisini ve bu etkinin, IMA düzeylerini değerlendirmedeki rolünü ortaya koymaktır. Gereç ve Yöntem: Troponin I yüksekliği olmadan akut koroner sendrom tanı kriterlerine sahip 63 hasta ve yaş olarak benzer 61 kontrol bireyi bu çalışmaya katıl-mıştır. İskemi modifiye albumin düzeyleri kolorimetrik metot ile ölçülmüştür. Bulgular: Hasta grubundaki serum iskemi modifiye albumin düzeyleri kontrol grubuna kıyasla anlamlı olarak yüksekti (Sırasıyla 0.644 ± 0.168 vs. 0.534 ± 0.116). Her ne kadar kontrol ve hasta grubunda sigara içenler daha yüksek iskemi modifiye albumin düzeylerine sahip olsalar da bu fark istatistiksel olarak anlamlı değildi. Tartışma: Bu çalışma, akut koroner sendromlu hastalarda sigara içimi ve iskemi modifiye albumin düzeyleri arasındaki ilişkiyi değer-lendiren ilk çalışmadır. Bu çalışmada, akut koroner sendromlu hastalarda sigara içiminin iskemi modifiye albumin düzeyleri üzerine hiçbir etkisinin olmadığı saptanmıştır. Anahtar KelimelerAkut Koroner Sendrom, İskemi; Risk Faktör; Reaktif Oksijen Türleri; Kardiyovasküler Ölüm Abstract Aim: Acute coronary syndrome (ACS) is a clinical condition that exists signs and symptoms with acute chest pain and myocardial ischemia. Ischaemiamodified albumin (IMA) is a new diagnostic biochemical marker for acute coronary syndrome. It has been proposed that reactive oxygen species which occur in ischemia lead the formation of IMA. The aim of our study is to determine the levels of new cardiac ischemia marker IMA in ACS, the effect of smoking that is an event that leads to the formation of reactive oxygen species on IMA levels and the role of this effect on the interpretation of IMA results. Material and Method: 63 patients who met the acute coronary syndrome diagnosis criteria with no elevations of Troponin I, and 61 agematched control subjects were included in this study. Ischemia-modified albumin levels were determined with a colorimetric method. Results: Serum ischemia-modified albumin levels in the patient group were significantly higher compared to the control group (0.644 ± 0.168 vs. 0.534 ± 0.116, respectively). Although smokers have higher ischemia-modified albumin levels in the control and patient groups, this difference was not statistically different. Discussion: This is the first study evaluating the relationship between smoking and ischemia-modified albumin levels in acute coronary syndrome. In this study, smoking was found to have no effect on ischemia-modified albumin levels in patients with acute coronary syndrome.

Results: There was a positive correlation between cadmium and serum free thyroxine and triiodothyronine levels. There was a negative correlation between cadmium and serum alanine aminotransferase and vitamin B12 levels. Discussion: Cadmium exposure was found to lead to an increase in thyroid hormone levels.