Objective: The usage of synthetic cannabinoids (SCs) has increased both in Turkey and all worldwide. Here, we evaluate if SCs cause ventricular repolarization abnormalities using initial and after 12th-hour electrocardiograms in patients with acute intoxication of SCs. We examined changes in the QTc and cTp-e parameters to demonstrate ventricular repolarization effects of the usage of SCs. Material and Methods: We used a prospective study design. Twenty patients were included who visited the emergency department, complaining of clouding of consciousness after using SCs. The QT, QTc and Tp-e intervals and several other electrocardiographic parameters were measured at baseline and 12 hours after the usage of SCs. Results: The QRS duration was significantly decreased (102.1 ± 15.5 ms vs 95.0 ± 10.7 ms; p = 0.022). We noted a significant decrease in cQT measurements at the end of the 12th hour (426.6 ± 47.2 ms vs 390.4 ± 42.9 ms; p = 0.002). Similarly, the Tp-e and cTp-e values decreased significantly when SCs lost its acute effect (93.4 ± 21.1 ms vs 77.4 ± 21.0 ms; p = 0.014, 105.3 ± 28.5 ms vs 88.1 ± 21.5 ms; p = 0.01). Conclusions: The usage of SCs affects ventricular repolarization heterogeneity based on QTc and Tp-e intervals

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