Altered joint motion has been thought to be a contributing factor in the long-term development of osteoarthritis after ACL reconstruction. While many studies have quantified knee kinematics after ACL injury and reconstruction, there is limited in vivo data characterizing the effects of altered knee motion on cartilage thickness distributions. Thus, the objective of this study was to compare cartilage thickness distributions in two groups of patients with ACL reconstruction: one group in which subjects received a non-anatomic reconstruction that resulted in abnormal joint motion and another group in which subjects received an anatomically placed graft that more closely restored normal knee motion. Ten patients with anatomic graft placement (mean follow-up: 20 months) and 12 patients with non-anatomic graft placement (mean follow-up: 18 months) were scanned using high-resolution MR imaging. These images were used to generate 3D mesh models of both knees of each patient. The operative and contralateral knee models were registered to each other and a grid sampling system was used to make site-specific comparisons of cartilage thickness. Patients in the non-anatomic graft placement group demonstrated a significant decrease in cartilage thickness along the medial intercondylar notch in the operative knee relative to the intact knee (8%). In the anatomic graft placement group, no significant changes were observed. These findings suggest that restoring normal knee motion after ACL injury may help to slow the progression of degeneration. Therefore, graft placement may have important implications on the development of osteoarthritis after ACL reconstruction.

We aimed at evaluating the cardiovascular and metabolic responses to sub-maximal exercise tests in untrained non-athletic young adults and comparing them with those of trained and more active soccer players. Forty healthy young adult males (20 untrained non-athletic undergraduates and 20 trained soccer players) aged 20-35 years participated in the study. The participants performed the exercise tests using a mechanically braked magnetic ergometer bicycle. Blood pressure and heart rate (HR) of participants were measured at rest and during the exercise test. The steady-state oxygen uptake (VO2SS) of subjects was estimated from a standardised sub-maximal VO2 equation. Data indicated significantly (P<0.05) higher absolute VO2SS, relative VO2SS, work rate, exercise oxygen pulse and cardiac output, but lower steady-state HR and %HRmax among the soccer players compared with the untrained individuals. No significant differences were observed in exercise systolic blood pressure, rate pressure product, resting HR reserve and %HR reserve between the two groups. Pearson’s partial correlation test indicted independent relationships between VO2SS (relative and absolute) and oxygen pulse, steady-state HR, percentage of HRmax, percentage of HR reserve, resting HR and working HR reserve respectively. The present study indicated greater cardio-metabolic responses to sub-maximal exercise and higher aerobic fitness in trained soccer players compared with the untrained non-athletic individuals.

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