No abstract

Part I describes measurements of the shape and rate of rise of air bubbles varying in volume from 1·5 to 200 cm. 3 when they rise through nitrobenzene or water. Measurements of photographs of bubbles formed in nitrobenzene show that the greater part of the upper surface is always spherical. A theoretical discussion, based on the assumption that the pressure over the front of the bubble is the same as that in ideal hydrodynamic flow round a sphere, shows that the velocity of rise, U , should be related to the radius of curvature, R , in the region of the vertex, by the equation U = 2/3√( gR ); the agreement between this relationship and the experimental results is excellent. For geometrically similar bubbles of such large diameter that the drag coefficient would be independent of Reynolds’s number, it would be expected that U would be proportional to the sixth root of the volume, V ; measurements of eighty-eight bubbles show considerable scatter in the values of U/V 1/6 , although there is no systematic variation in the value of this ratio with the volume. Part II. Though the characteristics of a large bubble are associated with the observed fact that the hydrodynamic pressure on the front of a spherical cap moving through a fluid is nearly the same as that on a complete sphere, the mechanics of a rising bubble cannot be completely understood till the observed pressure distribution on a spherical cap is understood. Failing this, the case of a large bubble running up a circular tube filled with water and emptying at the bottom is capable of being analyzed completely because the bubble is not then followed by a wake. An approxim ate calculation shows that the velocity U of rise is U = 0·46 √( ga ), where a is the radius of the tube. Experiments with a tube 7·9 cm. diameter gave values of U from 29·1 to 30·6 cm./sec., corresponding with values of U /√( ga ) from 0·466 to 0·490.

CLINICAL SIGNIFICANCE: Response and survival rates of inoperable canine MCT to chlorambucil and prednisolone are comparable to previously described protocols, with no apparent toxicity.

Tumour suppressor in lung cancer-1 (TSLC1) is a tumour-suppressor gene coding for an adhesion molecule that is expressed by mast cells. Reduced TSLC1 expression is associated with a poor prognosis in several human tumours, and this study sought to investigate if TSLC1 expression could be used to predict outcome in dogs with mast cell tumours (MCTs). Sections of MCTs of different tumour grades from 45 dogs (Group 1) were immunohistochemically assessed for TSLC1 and Ki67 expression. In addition, 35 intermediate-grade MCTs (Group 2) from dogs with known clinical follow-up were immunohistochemically stained for TSLC1 and Ki67. The TSLC1 staining intensity was found to strongly inversely correlate with tumour grade for Group 1 (P = 0.002857). For Group 2 there was a trend towards dogs with lower TSLC1 scores being more likely to die from MCT-related disease (P = 0.058). The intensity of TSLC1 staining inversely correlated with Ki67 expression for both groups.