Using microradioautography, the origin of the gastric parietal (and zymogen) cells was deduced by observing the time of appearance of labelled parietal cells in relation to the other labelled cells i n the gastric mucosa. In order to see whether the parietal cell divides in the adult mouse, time grain count curves of the labelled parietal cells were made from animals which were killed at 1-291 days after thymidine SH injection DPT). Parietal cell survival was followed by observing the disappearance of the labelled parietal cell population. Parietal cells appear to be entirely derived from other cells since a significant number of labelled parietal cells does not appear unless the animal is allowed to survive for several days. Parietal cells do not seem to undergo mitosis in the adult mouse because the time grain count curves did not shift with time. Although a few labelled parietal cells persisted in the 291 DPT animals, a large majority of the labelled parietal cells disappeared by 90 DPT and had a half life of roughly 23 days. This suggests an element of renewal for the parietal cell population.

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