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Background Local nonsurgical tumor ablation currently represents a further option for the treatment of patients with liver tumors or metastases. Electrochemotherapy (ECT) is a welcome addition to the portfolio of local therapies. A retrospective analysis of patients with liver tumors or metastases treated with ECT is reported. Attention is given to the safety and efficacy of the treatment over time. Patients and methods Eighteen consecutive patients were recruited with measurable liver tumors of different histopatologic origins, mainly colorectal cancer, breast cancer, and hepatocellular cancer. They were treated with percutaneous ECT following the standard operating procedures (SOP) for ECT under general anaesthesia and muscle relaxation. Treatment planning was performed based on MRI preoperative images. The follow-up assessment included contrast-enhanced MR within at least 1–3 months after treatment and then after 5, 7, 9, 12, and 18 months until progression of the disease or death. Results Only mild or moderate side effects were observed after ECT. The objective response rate was 85.7% (complete response 61.9%, partial 23.8%), the mean progression-free survival (PFS) was 9.0 ± 8.2 months, and the overall survival (OS) was 11.3 ± 8.6 months. ECT performed best (PFS and OS) in lesions within 3 and 6 cm diameters (p = 0.0242, p = 0.0297) . The effectiveness of ECT was independent of the localization of the lesions: distant, close or adjacent to vital structures. Progression-free survival and overall survival were independent of the primary histology considered. Conclusions Electrochemotherapy provides an effective valuable option for the treatment of unresectable liver metastases not amenable to other ablative techniques.

During the cooling process of the molten material, residual stresses appear because the reduced volume of the cooled material cannot fully fill the space formerly occupied by the molten material. The morphology in and around the weld is formed by different factors depending on the material and process parameters. Different morphological structures relate to different mechanical properties. The process parameters and the welding results including morphology and residual stress are linked together. In this article, residual stresses and the mechanical properties of a hot-plate-welded polypropylene specimen with 0.1 wt.-% content of carbon black are investigated in relation to the morphology. Different measurement positions and joining displacements of parts to be joined result in different residual stress states and morphological structures. The higher the joining displacement, the higher the residual stress. Investigations of the morphology show a relation between the size of the alpha spherulites and the joining displacement. Diffractions patterns of wide-angle X-ray scattering (WAXS) are not able to resolve the beta phase of the specimen.

This work presents the mechanical behavior of self-reinforced composites (SRCs) manufactured and modified via film stacking. For modification, interleaved films made of polypropylene (PP), a thermoplastic elastomer and a polyolefin engage were combined in different ways to induce the elastic modifier into the matrix material. The content of modifier was also varied in two ways. First, the films were produced out of a single material and second out of a compound. So, the same content of modifier was implemented in two different ways. It is shown that, in case of this research, only the kind of modifier and the content but not the way of implementation are responsible for the mechanical behavior of SRCs. It is shown that the modification can adjust the tensile strength, tensile stiffness and impact properties in a broad range. It is also shown that different mechanical properties of the composite can be predicted by a regression model that uses the Shore A hardness and the content of modifier.

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