No abstract

Objective: Mitosis is a fundamental age-related process. Mitoses are in different tissues and they are regulated by mediators. Mediators, for example, cytokines, hormones, are used as drugs for cancer, graft-versus-host disease and other diseases. Our goal is to assess available research pertinent to age-related mitoses, cytokines and hormones in lymph (body fluid), in particular, in thoracic duct lymph (TDL) in norm and use them in new drug design and development. Methods:We investigated the data banks of PubMed/Medline, World Cat, Google and Index Copernicus searching for articles published in the past four decades.Results: Three articles described some morphological properties and quantitative changes of age related mitoses in TDL in norm. One research was dedicated to quantitative and morphological features of TDL lymphocytes in norm and thyroxintreated. Several studies were focused on physiology of angiotensins, insulin, steroid hormones. A lot of latest publications focus on mediators of proliferation and mitosis. Interleukins are being researched in lymph in antigen-stimulation and other impacts. Age influence on immunity system, on mitoses in particular was revealed. In spite of the progress in the field of drug design there is a view about unsuccessful attempts to solve some problems by reductionist methods. The development of drug design needs to accomplish several complex multistep schemes, control cytotoxicities and then compare the results. Conclusion:The above mentioned data show the immune system changes with age, in norm and in impact. The changes and difference of TDL mitosis mediators in norm of mature and immature organisms have not been studied. It is necessary to develop new drug components. It is suggested that the changes and difference of TDL mitosis mediators between healthy newborn (neonatal, immature) and adults (mature) can be used to get a key to new drug design for cancer, graft-versus-host disease and other diseases.