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Introduction Anchorage loss is a reciprocal reaction that could obstruct the success of orthodontic treatment by complicating the anteroposterior correction of the malocclusion and possibly detracting from facial esthetics. 1 Many attempts have been done to increase anchorage by studying the effects of different systemic or local application of medications or the intake of dietary supplements, such as vitamins, 2 minerals, 3 hormones, 4 proteins 5 and immunomodulators 6 on the rate of tooth movement during orthodontic treatment. Kohno et al 7 injected anti-vascular endothelial growth factor antibody into the buccal gingival groove of experimentally moved teeth in mice. Clinically there was reduction in the amount of tooth movement and in the relapse, and the histological section demonstrated a significant decrease in the number of osteoclasts. Liu et al 8 used Clodronate solution as a local injection into the subperiosteal area adjacent to the left upper molar of rats in a dose of 2.5, 10 and 40 mM which subjected to orthodontic movement with a standardized expansion spring. Clinically there was a significant and dose dependent reduction in tooth movement in the experimental rats. The local injection of epidermal growth factor in liposome in a dose of 2 ng/µl into the region of root furcation of the left first molar of Wister rats after elastic band insertion led to increase in the rate of osteoclast recruitment, producing faster bone resorption and tooth movement. 9 Bone sialoprotein (BSP) is a highly sulfated, phosphorylated, and glycosylated protein that is expressed almost in Background and objective: Bone sialoprotein is a mineralized tissue-specific protein expressed in differentiated osteoblasts that appear to function in the initial mineralization of bone. The aim of this study was to investigate the effect of local bone sialoprotein on increasing the rate of anchorage during orthodontic tooth movement. Methods: This study used 14 dogs wearing orthodontic appliance for 40 days. They were divided equally into two groups; experimental group that injected with 0.1 µg /10µL sialoprotein around the anchoring tooth in three different time intervals, while the other control group received normal saline injection. Different clinical measurements including loss of anchorage, space closure, rotation, tipping and extrusion were done on the stone casts of each dog before and after tooth retraction. Results: Clinical measurements revealed a highly significant difference between experimental and control group regarding loss of anchorage and space closure. The sialoprotein injected group showed less loss of anchorage than control group and the space closure was higher in experimental group than in the control group. Conclusion: This study showed that the local injection of sialoiprotein reduced movement of the anchoring tooth during orthodontic treatment and provided higher stability for the anchoring tooth.