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Introduction: Pediatric acupuncture is an interesting subject to study along with strengthening the current development of acupuncture therapy. Not only for adults, but acupuncture is also safe for children. There have been many studies on acupuncture, but publications related to acupuncture for children are still very few compared to adults. The purpose of this study is to visually map and guide future research on Pediatric acupuncture based on bibliometric analysis. Method: We conducted this study from September 16 to 19, 2022. Publications regarding pediatric acupuncture were extracted from the Scopus database. The search strategy included two keywords: (ACUPUNCTURE)*(PEDIATRIC). The final result was acquired by searching those keywords without limitation because the number of articles was less than 1000. We used VOSviewer and bibliometric indicators to generate a maps-based data network from all keywords-related studies showing association among journals, countries, publication frequency, authors, and citations. Keywords were used to infer pediatric acupuncture. A total of 669 documents related to pediatric acupuncture were retrieved. This includes 432 articles, 176 reviews, and 16 conference papers. Results: A total of 10,918 citations have been recorded for all publications with an h-index count of 52. The first relevant study is dated on 1966. Since then, there has been a steady increase in total publications each year whereas 2021 as the most productive year with 53 publications. The Medical Acupuncture Journal (25) was the most prolific journal. The United States of America (298) and China (54) are the most productive country and institutions. The article entitled Clinical Practice Guideline: Allergic rhinitis by Seidman et al. (386) is the most cited reference.   Conclusion: The benefit and potential of acupuncture for several diseases in pediatric patients are promising and no adverse side effects have been reported.

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Background: Omphalopagus is a rare condition involving digestive system and abdominal wall fusion. This study reports an omphalopagus case during the early phase of the coronavirus disease 2019 (COVID-19) pandemic in Indonesia.Case: Male conjoined twins, aged 14 months, were diagnosed with omphalopagus and several organ failures. We performed separation surgery of the omphalopagus with primary closure and post-surgical care for fifteen days. The early surgery was preferable in this case due to life-threatening issues of COVID-19, despite omphalopagus separation may cause post-surgical complications. Furthermore, the emerging pandemic conditions also required a more stringent procedure to avoid the risk of viral spread.Conclusion: We conclude that, in the lack of evidence-based instruction for hospital care during the early phase of COVID-19 in Indonesia, life-saving surgical considerations from death due to complications of COVID-19 infection and acute respiratory distress syndrome must be performed and prioritized. However, potential omphalopagus complications must be evaluated.

Factor VIII (FVIII) inhibitor causes FVIII replacement therapy to be ineffective in Hemophilia A (HA) patients. Single nucleotide polymorphisms (SNPs) of several cytokine genes have been found for the FVIII inhibitor development risk. This study aims to determine if interleukin-2 (IL-2) (rs2069762) gene SNP is associated with FVIII inhibitor development in Indonesian patients with severe HA. The IL-2 (rs2069762) gene SNP was examined in 119 patients. The participants were divided into FVIII inhibitor positive (n = 59) and negative (n = 60) groups. We used peripheral blood mononuclear cells samples and employed tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) to determine the sample genotype. The IL-2 (rs2069762) gene polymorphism analysis did not show a significant association between FVIII inhibitor development risk and genotypes (p = 0.138) and alleles (p = 0.780) frequencies. IL-2 (rs2069762) gene polymorphism is not related with FVIII inhibitor development in Indonesian patients with severe HA. Thus, further polymorphism studies are required to analyze others FVIII inhibitor-related cytokine genes.