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The age of technological advancement has led to the rapid development of new media. Among them, video games have both positive and negative effects on children's growth and development. Research shows that: playing video games has a positive bearing on the basic mental processes such as decisionmaking, perception, memory, and attention; by inculcating some idea development skills into the little minds, video games make children's thinking ability more acute; in cognitive development, video games facilitate the social development of children and avert risks such as stress and depression; in cooperative model of video games, children can understand the value of cooperation in the process of growing up, so as to achieve better results. However, the longer the time children spend playing games, the poorer they become in school; video games will also lower children's attainment of information, promote children's violence, antisocial behavior and social isolation. In a word, it has been proven that video games contribute to the positive development of children through the inculcation of values such as resilience and positive competition. These games have also taught children the value of teamwork and cooperation, which are important skills in child development. At the same time, video games also promote violence, reduce professional social behavior, and even cause poor performance in school. It is in this context that video games should be rationally evaluated.

This bibliometric study aimed to summarize and visualize the current research status, emerging trends and research hotspots of regulatory T (Treg) cells in neurological diseases. Relevant documents were retrieved from the Web of Science Core Collection. Tableau Public, VOSviewer and CiteSpace software were applied to perform bibliometric analysis and network visualization. A total of 2739 documents were included, and research on Treg cells in neurological diseases is still in a prolific period. The documents included in the research were sourced from 85 countries/regions, with the majority of them originating from the United States, and 2811 organizations, with a significant proportion of them coming from Harvard Medical School. Despite being the most prolific author in this research area, Gendelman HE had relatively few collaborations with researchers from other organizations. Considering the number of documents and citations, impact factors and JCR partitions, Frontiers in Immunology was the most popular journal in this research area. Keywords “multiple sclerosis”, “inflammation”, “regulatory T cells”, “neuroinflammation”, “autoimmunity”, “cytokines” and “immunomodulation” were identified as high frequency keywords. Additionally, “gut microbiota” has recently emerged as a new topic of interest. The study of Treg cells in neurological diseases continues to be a hot topic. Immunomodulation, gut microbiota, and cytokines represent the current research hotspots and frontiers in this field. Treg cell-based immunomodulatory approaches have shown immense potential in the treatment of neurological diseases. Modifying gut microbiota or regulating cytokines to boost the numbers and functions of Treg cells represents a promising therapeutic strategy for neurological diseases.