Polar
coatings are used to protect surfaces from marine fouling
based on the formation of a hydrated surface layer, which acts as
a barrier to marine microorganisms. In this context, we have developed
a material with glucose bound to ferrocene to prevent surface absorption.
Glucose brings the polarity while ferrocene has the role of varying
the state of charge of the surface. We therefore describe the synthesis
of 6-deoxy-6-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-1-(4-aminophenyl)-β-D-glucopyranose 6 and its immobilization on the surface of a C electrode and
develop a methodology used for antibacterial testing. We were able
to demonstrate that the immobilization of glucose 6 could
be done in an artificial seawater environment by oxidation of an amine.
The use of a 96-microwell platform equipped with electrodes for cyclic
voltammetry, linked to a potentiostat, allowed the electrical solicitation
of the coating in the presence of marine bacteria with a greater number
of biological replicates. We have shown that the coating has an antibacterial
effect, and this effect is accentuated when the coating is electrically
stressed, resulting in the appearance and disappearance of charge
on ferrocene, a phenomenon that seems to be conducive to colonization
by bacteria.
Carbohydrate–ferrocene conjugates show a splitting of all the 1H NMR signals of the substituted cyclopentadienyl. XRD of crystals seems to indicate that the R group could be responsible for the splitting of the NMR signals.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.