Stress is a psychiatric/psychological disorder characterized by a sense of disability, despair, anhedonia, decreased activity, and pessimism. Stress can affect the physiological condition of the body with symptoms of lipid metabolism disorders. Chlorella vulgaris is a microalgae that is known to have the potential as an alternative antidepressant drug. The study was conducted to determine the lipid profile of blood wistar strain rats after stress induction and the effect of administration of Chlorella vulgaris on blood lipid profiles of stress-induced wistar rats. This research is an experimental study using 5 treatments with 25 models of Rattus norvegicus wistar strain, 2 months old. The treatment group consisted of 1 control group, 1 stress group, and 3 groups of treatment variations, namely the treatment of antidepressant medication, the treatment of administration of cultivated Chlorella vulgaris, and the treatment of commercial Chlorella. Stress induction is carried out by treatments that given to the rats randomly, namely cold water, warm water, wet cage, dark-light cycle, and sound wave exposure for 40 days. Examination of blood lipid profiles was carried out on Day 0 after mice were acclimated, day 40 after rats were induced stress, and day 56 after rats were given treatment of cultivated Chlorella vulgaris. The results obtained were the stress conditions of the lipid profile of the wistar strain of rats which had increased were total cholesterol levels of the control group and triglyceride levels in all groups while those who had decreased were cholesterol levels other than the control group, HDL levels in all groups, and LDL levels all groups. Giving Chlorella vulgaris had effect on decreasing total cholesterol levels, triglyceride levels, and LDL levels along with increasing HDL levels.

Biologi merupakan mata pelajaran dengan sumber belajar yang berkaitan dengan semua makhluk hidup beserta interaksinya yang dekat sekali dengan kehidupan sehari-hari. Potensi lokal dapat digunakan sebagai sumber belajar biologi yang menarik dan dekat dengan siswa. Materi biologi khususnya keanekaragaman jamur belum banyak dikaitkan dalam kehidupan sehari-hari sehingga hanya terpaku pada buku teks. Memadukan materi biologi dengan potensi lokal berpotensi dapat meningkatkan minat dan hasil belajar siswa. Tujuan artikel ini adalah untuk mengetahui keanekaragaman jamur yang ada di Agrowisata Jejamuran Yogyakarta, sehingga Agrowisata Jejamuran dapat menjadi sumber belajar berbasis potensi lokal pada mata pelajaran biologi  Jenis penelitian ini merupakan deskriptif kualitatif. Penelitian tahap 1 dilakukan survei awal, penentuan lokasi sampling, inventarisasi potensi lokal. Tahap 2 adalah analisis potensi keanekaragaman jamur sebagai sumber belajar biologi melalui studi literatur. Metode yang digunakan dalam pengumpulan data yaitu memadukan antara hasil survei, wawancara, serta literatur terkait. Berdasarkan hasil penelitian, potensi lokal jamur di Agrowisata Jejamuran terdapat 12 jenis jamur. Keanekaragaman jamur yang terdapat di Agrowisata Jejamuran dapat dijadikan sumber belajar mata pelajaran Biologi berbasis potensi lokal. Berdasarkan pembahasan, dapat disimpulkan bahwa Agrowisata Jejamuran dapat digunakan sebagai sumber belajar biologi berbasis potensi lokal pada materi jamur melalui fieldtrip, pembuatan media realia jamur, modul, maupun video.

targeted alpha-particle radiation therapy for LMGC in a preclinical mouse model. Material and methods Astatine-211 (At-211), an alpha-particle emitter radionuclide, was produced by irradiation of alpha-particles to bismuth-209 using an AVF accelerator at our institute. An anti-HER2 antibody trastuzumab was conjugated with At-211 to produce alpha-emitting antibodies targeting HER2 ([At-211]-trastuzumab). To generate a mouse model of LMGC, we injected luciferase-labelled HER2-positive human metastatic NCI-N87 GC cells into splenic vein of severe combined immunodeficiency mouse. Tissue and tumour distribution of [At-211]-trastuzumab was examined in the LMGC mouse model. Therapeutic efficacy and toxicities of [At-211]-trastuzumab were evaluated in the animal model. All animal experiments conducted in this study were approved by the Animal Care and Use Committee of our institute and were undertaken in compliance with the institutional guidelines regarding animal care and handling. Results and discussions Biodistribution studies showed that the maximum uptake of trastuzumab in the liver metastatic tumours was approximately 12% of injected dose per tissue gram at 24 hours after injection.A systemic injection of [At-211]trastuzumab (1 MBq) significantly reduced a tumour burden in the liver and extended the survival of model mouse. Transient leukocytopenia was observed in mice received 1 MBq of [At-211]trastuzumab at 5-7 days after injection. No body weight loss was so far found in the mice treated with [At-211]trastuzumab. Conclusion Our preclinical study provides the evidence that targeted alpha-therapy using [At-211]-trastuzumab is effective for LMGC.