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The present study aims to detecting several biochemical markers and cytokines in obese and normal lean Iraqi women. Forty women (02 obese and 02 lean) were chosen from different areas in Baghdad city there ages ranges between 02-73 years and body mass index (BMI) between 02.32-72.3 Kg/m². The study showed a high significant increment in Fasting Blood Glucose (FBG), serum cholesterol and Homeostasis Model Assessment (HOMA) in obese women as compared with lean and a significant increment in HDL (High Density Lipoprotein) in lean women when compared with obese ones. A significant correlation coefficient (r) was noticed between BMI and studied parameters, FBG, cholesterol, triglyceride, insulin, HOMA, high sensitive C Reactive Protein (hs-CRP), Tumor Necrosis Factor alfa (TNF-α) and IL-3.

Plantago laceolata considered as an ancient herb promising plant. In this work, the target of the study was designed to estimate total flavonoids, anti-oxidant and chemical composition of Plantago laceolata aqueous extract in vitro. Total flavonoids content was;evaluated in the extract, and it was 317.0000 ± 9.64365mg /ml. also, anti-oxidant activity of Plantago laceolata aqueous extract in vitro was assessed in vitro via evaluation of reductive ability. At all concentrations of plant extract tested (0.02, 0.04, 0.08, 0.16, 0.32 and 0.64 mg/ml) in reductive ability; the absorbance was increase significantly in all dependent concentration manner. also, the aqueous plant extract was increase significantly The results of chemical composition of plant showed contain Tannins, polysaccharide, Alkaloids,Flavonoids and Polyphenolic Compounds . Also plant extracts counteract the damage caused by methotrexate drug through the reduction in liver enzymes GOT, GPT and ALP in all groups of mice the results of interactions indicated the ability of plant to modulating harmful effects of the drug in liver and its enzymes when administration to albino mice male in 200mg/kg.

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