Background: Prostate cancer is the second most common male cancer. Prostate cancer is diagnosed via a digital rectal exam, ultrasonography, and serum prostate specific antigen. Dr. Donald Gleason devised a prostate cancer grading system over 50 years ago. This system is still viable with modifications. The ISUP updated in 2005 and 2015. Gleason score and prognosis in prostatectomy stuff Gleason score, tumor volume, and tumor laterality were compared. nephroscopy and prostate Method: The study comprised 42 men with biopsy and prostatectomy materials. Gleason's grade. The new method graded tumors. Between october2019 and October 2021, 42 individuals with prostate cancer were needle biopsy diagnosed and treated with RP. Tumor volume was measured by the number of positive blocks. A significant difference in diagnosed by digital imaging, serum prostate specific antigen, and needle biopsy. Gleason score, location, and volume are unknown tumor features. Result: Gleason score, tumor volume, and laterality between needle biopsy and prostatectomy materials Gleason score and tumor volume enhanced concordance. Conclusion: For a prostate cancer diagnosis, a digital exam, serum PSA and needle biopsy are quite sensitive. Lesser known tumor characteristics include Gleason score, location, and volume. Keywords: Prostate, Adenocarcinoma, Needle biopsy, Radical prostatectomy, Gleason score

Percutaneous nephrolithotomy (PCNL) is considered as the gold standard treatment for renal stones > 2cm. We encountered a patient who underwent PCNL and inadvertently placement ofpercutaneous nephrostomy tube in the inferior vena cava through the left renal vein from the left Kidney.There was profuse bleeding during the procedure (PCNL), and the procedure was abandoned by placing a nephrostomy tube. PNT was removed after 04 days in two steps without any bleeding.

Objective: To determine the frequency of postoperative residual stone based on preprocedural Guy’s scoring system.Methodology: This cross-sectional descriptive study was conducted from1st June 2018 to 30th November 2019 at University Medical College Faisalabad. All patients with stones in the kidney undergoing PCNL, 20 to 60 years of age of both genders were included. Patients with secondary stones due to pelviureteric junction obstruction, CRF and recurrent stones were excluded. In all patients Guy’s scoring was measured. Then all patients underwent PCNL. After 24 hours of operation, CT scan was done in each patient and residual stone (present/absent) was noted.Results: This study was comprised of 91 patients of age ranged from 20- 60 years. Fifty-three patients (58.24%) were males and 38 (41.76%) females. Seven (7.69%) were of Guy’s grade I, 48(52.75%) grade II, 21(23.08%) grade III and 15 of grade IV. Number of patients with residual stone was 09 (9.89%), 0.0% of GS 1, 12.5% of GS 2, 4.76% of GS 3 and 13.33% of GS 4 patients had residual stone.Conclusion: Pre-PCNL Guy’s scoring is easy, rapid and useful for predicting the residual stone after percutaneous nephrolithotomy. Keywords: Percutaneous nephrolithotomy, Guy’s scoring system, residual stone.

Urethral calculi are rare and represent 1-2% of all urinary stone diseases. Rarely, calculus grows to large size and are labeled as a "giant urethral calculus". A 75-year-old male came to the OPD of Madinah Teaching Hospital Faisalabad with a chief complaint of suprapubic pain, penile pain, and hard mass on the left side of the scrotum and anterior perineum. The patient had a significant history of undergoing debridement for Meleney's and Fournier's gangrene, along with suprapubic cystostomy done about 1.5 years back. Physical examination revealed a solid mass with dimensions 6x7 cm on the left side of the scrotum and anterior perineum (left periurethral area). Open surgery was performed. A huge stone, 6x6cm, was removed. Diverticulae were excised, and urethroplasty was performed. A catheter was removed on the 21st postoperative with a satisfactory urinary stream.