Introduction: According to the importance of knowledge about incidence and mortality of oral cavity and lip cancer in health planning, this study was performed with the aim of investigating the incidence and mortality rate of oral cavity and lip cancer and its relation with the Human Development Index in the world in 2012. Methods: The study was conducted based on data from the world data of cancer and the World Bank (including the HDI and its components). Data about the age-specific incidence and mortality rate (ASR) for every country in 2012 were getting from the global cancer project. To analyze data, correlation tests between incidence and death rates, and HDI and its components were employed with a significance level of 0.05 using SPSS software. Results: In 2012, 300373 cases of oral cavity and lip cancer and 145353 cases of death from it have occurred in the world. A positive correlation of 0.221 was seen between the standardized incidence rate of oral cavity and lip cancer and HDI but this correlation was not statistically significant (p=0.114). On the other side, a correlation of 0.295 was seen between the standardized mortality rate of oral cavity and lip cancer with HDI that this correlation was statistically significant (p<0.001). Conclusion: The incidence and mortality of oral cavity cancer is high in the Asian countries especially south eastern of Asia. Performing preventive plans in high incidence and mortality rate regions and also obtaining etiological studies in these regions is recommended for diagnosing the causes of high incidence and mortality rates.

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