Wound healing is a complicated procedure which necessitates laying out a suitable wound healing system or dressing which possesses key factors like a wet wound location, avoidance of microbial action and absorption of exudates. Various wound dressings can be accessible but not all can meet the particular conditions of a perfect wound healing system to complete proper wound healing process. Poly(Lactic Acid) (PLA) Nano Structure Mats are a new class of materials that possess great potential in wound healing because of biocompatibility, bio absorbability, biodegradability, absorption of exudates from the wound, physical safety of the wounded tissue and the probability to free useful molecules. Our review article gives a brief intro on the wound and skin structure and afterwards gives information about the peerless characteristics of PLA Nano Structure Mats remarkable for wound healing. Moreover, new recent investigations about PLA Nano Structure Mats usage for wound healing applications were also explored.Yara iyileşmesi, ıslak bir yara yeri, mikrobiyal etkiden kaçınma ve eksüdaların emilmesi gibi anahtar faktörlere sahip uygun bir yara iyileştirme sisteminin veya uygun yara pansumanın yapılmasını gerektiren karmaşık bir prosedürdür. Yaralar için çeşitli yara pansuman malzemeleri kullanılabilir, ancak bunların hepsi uygun yara iyileşme sürecini tamamlamak için mükemmel bir yara iyileşme sisteminin belirli koşullarını karşılayamayabilir. Poli(Laktik Asit) (PLA) nano yapı matları, biyouyumluluk, biyo emilebilirlik, biyobozunurluk, sızıntıların yaradan emilmesi, yara dokusunun fiziksel emniyeti ve faydalı molekülleri salabilme olasılığından dolayı yara iyileşmesinde büyük potansiyele sahip yeni bir malzeme sınıfıdır. Bu derleme makalesinde, yara ve cilt yapısı hakkında kısa bir giriş yapıldıktan sonra yara iyileşmesinde dikkat çeken PLA nano yapı matlarının benzersiz özellikleri hakkında bilgi verilmektedir. Ayrıca, PLA nano yapı matlarının yara iyileşme uygulamaları için kullanımı ile ilgili son araştırmalar da ayrıntılı olarak incelenmiştir.
There is need to address the challenges of organ shortage, through development of tissues and organs with alternatives to those of the allograft-kind. This illustrates the quest behind novel biofabrication strategies such as 3D bio-printing, which is necessary to create artificial multi-cellular tissues/organs. Several findings have been reported in this review. First, the role of ECM components in tissue regenerative medicine is presented. Different ECM components such as collagen, gelatin, elastin, fibronectin, laminins and glycosaminoglycans are concisely examined for their tissue regenerative medicine applications. Next, current state of research on extrusion-based 3D bio-printing techniques and their limitations are reviewed. For example, we show that cell viability is still a challenge with extrusion, while the use of natural polymers such as collagen in improving composites’ mechanical properties is limited. Lastly, we examine unresolved research questions necessary to advance the present state of research in the field.
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