The rapid development of the construction world in Indonesia raises the need for more effective supporting technologies. One example of technology support in the construction world is the application of Building Information Modelling. With this background, the research was made using the implementation of BIM on a project, in order to increase the digitization of the construction world in the future. By using various BIM software such as Allplan engineer, Allplan Bridge, Openroads Bentley, and Synchro. The result is that the alternative bridge design is declared feasible because there are no conflicts in the superposition analysis with the BIM software approach, interviews with experts and BINA MARGA criteria. After the application of the BIM Software, the results shows there is an increase of for the volume of concrete material, volume of reinforcement weight, and the cost, this is caused by a more accurate design for the model.

Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-κB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-κB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-κB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-κB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-κB expression and MVD. Results: Positive NF-κB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-κB and MVD. Conclusion: This study has not confirmed any correlation between NF-κB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.