Introduction: NPC is a highly prevalent malignant disease in endemic regions such as Southeast Asia. Until now, most NPC patients have bben diagnosed in advanced stages. Early-stage NPC is difficult to diagnose clinically. The study present a case of early-stage NPC with the symptoms of progressive ringing in the ear. Case report: A 56 years old male presented with two months history of progressive unilateral ringing in the ear. The patient had been previously diagnosed and treated for Eustachian tube dysfunction. Endoscopic examination of nasopharynx showed a mass in the left fossae of Rosenmüller. CT scan depicted soft tissue thickening on the left side of the nasopharynx. Nasopharyngeal histopathology revealed a non-keratinizing squamous cell carcinoma. The patient underwent radiotherapy and up to date, no complaints have been encountered. Conclusion: Early detection of NPC will improve patient’s prognosis.

Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-κB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-κB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-κB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-κB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-κB expression and MVD. Results: Positive NF-κB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-κB and MVD. Conclusion: This study has not confirmed any correlation between NF-κB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.