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Thermal conductivity of nanofluids depends on several parameters including temperature, concentration, and size of nanoparticles. Most of the proposed models utilized concentration and temperature as influential factors in their modeling. In this study, group method of data handling (GMDH) artificial neural networks is applied in order to model the dependency of thermal conductivity on the mentioned factors. Firstly, temperature and concentration considered as inputs and a model is represented. Afterwards, the size of nanoparticles is added to the input variables and the results are compared. Based on obtained results, GMDH is an appropriate method to predict thermal conductivity of the nanofluids. In addition, it is necessary to consider size of nanoparticles in order to have a more precise model.