Rational drug use is a very warm discussion in the health care system in Indonesia. This is possible because of reports of the occurrence of errors in the selection and use of drugs freely by the community without based on adequate knowledge, causing undesirable side effects. Real Teaching Action (RTA) is an effort to improve people's knowledge through short learning activities about drug information. The information conveyed among others is about the classification of drugs, the steps to use the drug "DAGUSIBU" (Get, Use, Save and Dispose of), self-medication and route of administration of the drug. The measurement method used is a pretest and posttest design to measure the success rate of the program which is divided into 5 measurements. The location used as an activity is in Sendang Village, Purwantoro Subdistrict, Wonogiri Regency, Central Java, with the target of housewives who are then referred to as AKU (Superior Family Pharmacists) cadres. The results of the activity are known to have increased the knowledge of respondents through pretest-posttest with a percentage value of 27.19%-97%. So it can be concluded that the RTA approach is able to provide a good understanding of AKU cadre training