The design and synthesis of novel cyanopropyl polysilsesquioxane hollow spheres lead to production of a highly active and stable catalyst in the reduction of 4-nitrophenol catalyzed by Au nanoparticles.

Smart release on demand: A general pH‐responsive supramolecular nanovalve operating in aqueous media has been designed by using mesoporous organosilica hollow nanospheres as nanocontainers (see picture). The nanovalve is capable of storing guest molecules within the hollow core and mesopore shell and releasing them on demand by acid/base triggering of the capping molecule, demonstrating a delicate vehicle for controlled release.

ADAM8 causes TMZ resistance in GBM cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met. Specific ADAM8 inhibition can optimize TMZ chemotherapy of GBM in order to prevent formation of recurrent GBM in patients.