Results: CYP450 gene expression was significantly altered about 6 weeks postnatally between preterm infants (n=18) born at early (GA 25.2-28.6 wks) versus late (n=23) ). Thirteen CYP450 genes, including those metabolizing commonly used drugs, such as CYP1A2 (p=0.0112) and CYP3A4 (p=0.0424), differed in expression levels. No significant differences in CYP450 gene expressions among preterm males and females were found. Conclusion:We identified significant differences in CYP450 gene expression levels in preterm infants 6 weeks postnatally depending on GA. In particular CYP1A2 and CYP3A4 are interesting candidates for explaining variable drug response in preterm infants. Further investigation is needed to explore the role of these differences related to drug metabolism. Background and aims: Bronchopulmonary Dysplasia (BPD) is considered to be a consequence of prematurity, pulmonary baro/volutrama, hyperoxia and inflammation. Increased inflammatory response and lung repair with impaired alveolarization and vascularisation are largely determined by genetic variability. Metalloproteinases are endopeptidases with key role in extracellular matrix remodeling as occurs during lung development and repair after injury. The aim of this study was to assess the influence of MMP-2 and TIMP-2 genetic polymorphisms on the risk of BPD. 810Methods: 95 preterm neonates with a gestational age of ≤32 weeks and birth weight ≤1500g were included in this prospective study. For the evaluation of phenotypic effect 215 term healthy neonates were additionally included. Out of 95 premature infants 47 developed BPD according to NIH criteria. 7 neonates died before time of assessment presenting severe lung damage. Using SNP TaqMan assays -1306C/T MMP-2 and +853G/A TIMP-2 polymorphisms were genotyped in DNA extracted from blood samples.Results: Analysis of genetic variability in preterm neonates showed difference in distribution of genotypes at -1306C/T MMP-2 position. C/T and T/T genotypes were more frequent in neonates developing BPD or in those who died. Additionally T allel presence was associated with prolonged ventilation time and hospitalization duration at NICU. No difference in +853G/A TIMP-2 polymorphism frequency was found between tested groups.Conclusions: Based on presented data and multigenetic background of BPD, genetic variability of MMP-2 may be one of the contributory factors in development of bronchopulmonary dysplasia. Background and aims: Progressive muscular dystrophies represent a group of genetic diseases with insidious onset in childhood; they are characterized by muscle fatigue associated with pseudohypertrophy of the muscles, high level of creatinkinase; electrophysiological, histological and molecular biology studies distinguish the primary disorder of the muscles. 811

Table 1 Image modality and stroke type in a medical center Image MRA 73.91% (34/46) CTA 30.43% (14/46) Angiography 21.74% (10/46) Stroke type Ischemic type 63.04% (29/46) Haemorrhagic type 23.91% (11/46) Abstract 1517 Table 2 Surgical rate and Glasgow outcome scale Surgical type Percentage (N=46) Neovascularisation 15.22% (7/46) Removal of hematoma 19.57% (9/46) None 65.22% (30/46) Glasgow outcome scale Percentage (N=40) 5 40% (16/40) 4 42.5% (17/40) 3 2.5% (3/40) 2 2.5% (1/40) 1 5% (2/40) Conclusions MMD is commonly found in the Asian area, including Japan, Korea and Taiwan. However, the outcomes of patients with MMD are unpredictable. In this study, we found that the severity of MMD might be correlated with the scores of modified Suzuki's grading system. Therefore, the more the scores patients with MMD acquire, the higher risks of infarction will possibly occur in them.

therapy. Significant difference in FEV1% was found in these two groups. In our study, steroid naive children with asthma and normal FEV1% had eosinophilic inflammation in airways.

unavoidable. The positive identification of the aeroallergen that is responsible for allergic rhinitis symptoms is of great importance for choosing the right therapeutic approach.

Background and aimsFebrile seizures are the most common form of seizures in children. They occur in 2%–5% of children aged 6 months to 5 years. They are classically associated with a positive familial history of febrile seizures and high fever occurring during various acute infections.The aim of this study is to establish if febrile seizures are significant correlated with certain acute febrile diseases.MethodsA retrospective study was initiated including all the children admitted in ‘Dr.Victor Gomoiu’ Children’s Hospital for an acute febrile infection from January 2016 till January 2017; we have found a total of 4577 children.Among them those admitted for upper respiratory infection, lower respiratory infection, urinary tract infection, viral gingivostomatitis and viral enterocolitis were counted individually.Further in each category mentioned above those who also had a febrile seizure during the present acute febrile disease were counted.Finally the statistically significance of the correlation between each category of acute febrile disease listed above and the occurrence of febrile seizures was assessed (statistically significant: p<0,05).ResultsAmong those 4577 children admitted in our clinic 841 (18.37%) had upper respiratory infection, 2695 (58.88%) had lower respiratory infection, 160 (3.49%) had urinary tract infection, 75 (1.63%) had viral gingivostomatitis and 806 (17.6%) had viral enterocolitis.A total of 125 (2.73%) children had a febrile seizure; 70 (56%) of them had upper respiratory infection (p<0,01), 22 (17.6%) had lower respiratory infection (p<0,01), 5 (4%) had urinary tract infection (p=0,903), 6 (4.8%) had viral gingivostomatitis (p<0,05) and 22 (17.6%) had viral enterocolitis (p=0,99).ConclusionsRespiratory tract infections are the most frequent causes of fever in children admitted in our clinic for febrile seizures with a rate of 73.6%, followed by viral enterocolitis (17.6%),viral gingivostomatitis (4.8%), and urinary tract infection (4%).These results are in concordance with those from the most recent studies published in medical literature.