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Introduction Dengue fever is a viral infection transmitted by female mosquitoes of the Aedes aegypti and Aedes albopictus species. vector-borne diseases represent an impact on public health in Mexico and the world, so it has tried to contain and mitigate them. Objectives Analyze the epidemiological panorama of dengue in the 2019 season of the Guadalajara Civil Hospital 'Juan I. Menchaca'. Material and Methods A cross-sectional, analytical study was designed. The data search was carried out through the platform of the National Epidemiological Surveillance System (SINAVE), of all the cases notified as arbovirosis during the year 2019. The analysis was carried out with the EPI Info 7 statistical package, frequency measures were calculated and association. Results 1496 probable cases of dengue were reported, of which: non-serious dengue 108 (7.22%), dengue with alarm signs 197 (13.17%) and severe dengue 183 (14.9%), positivity of 488 cases (70%). Municipality of residence: Guadalajara 287 (58.81%), Tonalá 73 (14.95%), Tlaquepaque 60 (12.29%). Housewife represented 39.96% (OR 1.40, 95% CI 0.99-1.97, p 0.053), age (mean 30.78), male 60.83% (OR 0.77, 95% CI 0.54-1.09, p 0.14). Liver enzymes in patients with dengue fever: ALT 830.42 (mean difference 795.08, 95% CI 683.00-907.17, p < 0.0001), AST (mean difference 2368.83, 95% CI 1980.65-2757.01, p < 0.0001). Conclusions The high positivity reflects a high incidence of the disease during the 2019 season. Home occupation was highly prevalent, although it was not possible to demonstrate statistical significance as a risk factor for the disease, however, it opens the possibility of future research. Our study highlights the importance of including liver function tests as an initial evaluation since it was an important predictor of mortality. Key messages Dengue. Fever.