Background: We aimed to report our experience in uncontrolled donation after circulatory death (uDCD) kidney transplantation applying a strict donor selection and preservation criteria. Methods: All kidney recipients received a graft from a local uDCD. As controls, we included all renal transplants from local standard criteria donation after brain death (SDBD) donors. Normothermic regional perfusion was the preservation method in all cases. Results: A total of 19 kidneys from uDCD donors were included and 67 controls. Delayed graft function (DGF) was higher in the uDCD group (42.1% vs 17.9%; P = .033), whereas no differences were observed in primary nonfunction (0% cases vs 3% controls; P = .605). The estimated glomerular filtration rate was identical in both groups. No differences were observed in graft survival censored for death between the uDCD and the SDBD groups at 1-year (100% vs 95%) or 5-year follow-up (92% vs 91%). uDCD kidney recipients did not have higher risk of graft loss in the multivariate analysis adjusted by recipient age, cold ischemic time, presence of DGF, and second kidney transplant (HR: 0.4; 95% CI 0.02-6; P = .509). Conclusions: Obtaining renal grafts from uDCD is feasible in a small city and provides similar outcomes compared to standard DBD donors.
S everal authors have commented on the anatomical changes following r a d i c a l p r o s t a t e c t o m y ( R P ) f o r prostate cancer and their characteristic radiological appearances. 1,2 Most of these relate to periurethral fibrosis and its clinical significance in patients with postprostatectomy sphincter weakness incontinence. 3,4 On magnetic resonance imaging (MRI), this postsurgical fibrosis appears as a focus of low-signal intensity in the periurethral tissues at and around the level of the vesicourethral anastomosis (VUA) which is appreciable on both T1-and T2-weighted images.Another finding on MRI and fluoroscopy has become apparent to us in patients post-RP. We describe this radiological appearance as "funneling of the bladder neck, " and to the best of our knowledge, this has not been previously reported in the literature. In this contribution, we characterize this radiological observation and explain its clinical relevance in the interpretation of radiological imaging in patients following RP, particularly those with a bladder neck contracture (BNC). We outline the role these postsurgical anatomical changes impact the surgical management of these said contractures.
RADIOLOGICAL APPEARANCEPrior to RP, the bladder base (and prostate) appears flat and well-supported by a well-developed levator sling (Figure 1a) on MRI. Following prostatectomy, the bladder base no longer appears flat, but has a typical "funnel-shaped" appearance as demonstrated
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.