Cadmium (Cd) and lead (Pb) are heavy metals which used in many industry and were confirmed as environmental toxin and mainly effects reproductive system and toxic to growing fetus. Determination of cadmium and lead level generally measure by spectrophotometric methods. But in this study, we used a method based on approach adjusting specific gravity. This study aimed to evaluate the potential effect of cadmium and lead exposure on pregnancy outcome by measuring their correlation on renal function. This study was performed between January to May 2013 and targeted 57 pregnant women as the control group (32 patients of normal pregnancy) and case group (25 patients of preeclampsia). For analyzing of the data, SPSS software version 17 was used and was examined by Mann-Whitney test and Spearman correlation test. We found that there are significant correlation between Cd an Pb exposure on urea level, urea-creatinine ratio, and GFR of the pregnancy patients (p < 0,05) but unlike to the creatinine serum. 

Abstract-Cadmium (Cd) is a heavy metal, which is used in many industries and was confirmed as an environmental toxin and mainly effects haematological system and liver. Previous studies showed that Cd induced damage of the liver and influenced erythrocytes. The effect of Cd in haematological system and liver function especially in pregant women has not been much studied. Thus our study aimed to evaluate the potential effect of cadmium exposure on erythrocytes and liver function in pregnant women by measuring their correlation on the number of erythrocytes and the levels of Aspartate Transaminase (AST) and Alanine Transmainase (ALT). This study was performed between July to December 2013 and targeted 58 pregnant women who were admitted for treatment and termination of pregnancy due to medical or obstetrical indications in Mutiara Bunda Mother and Child Hospital, Martapura, South Kalimantan, Indoneseia. For analyzing of the data, SPSS software version 17 was used and was examined by Pearson correlation test. We found that Cd has a negative correlation with erythroctes cell count and ALT levels and a positive correlation with AST levels, but the three correlations are not significant on statistical analysis. It can be concluded from our results Cd caused erythrocytes cells and tissue damage but did not cause liver damage.Index Terms-Alanine transaminase, aspartate transmainase, cadmium, erythrocytes, pregnant women.