Kunyit putih (Curcuma zedoaria) adalah tanaman herbal yang banyak digunakan sebagai obat herbal di Asia, khasiatnya dipercaya dapat meningkatkan imun tubuh, sebagai anti nyeri dan anti inflamasi. Penggunaan obat herbal secara umum dipercayai oleh masyarakat memiliki efek samping cenderung rendah dibandingkan obat modern, akan tetapi belum ada banyak penelitian mengenai efek samping dari penggunaan kunyit putih. Kebaruan dalam penelitian ini karena meneliti uji akut ekstrak kunyit putih terhadap analisis gambaran histopatologi otot jantung. Penelitian ini bertujuan untuk menguji toksisitas akut dari ekstrak etanol rimpang kunyit putih terhadap gambaran histopatologi otot jantung. Penelitian menggunakan 30 ekor tikus putih (Rattus norvegicus) dengan berat antara 150-200 gr. Sampel dikelompokkan menjadi 2 kelompok kontrol dan 4 kelompok perlakuan. Perlakuan yang dilakukan yaitu pemberian aquades, NaCMC1%, dosis EKP 250 mg/KgBB, EKP 500 mg/KgBB, EKP 750mg/KgBB, dan EKP 2000 mg/KgBB. Parameter yang diamati adalah hiperemi, hemoragi dan degenerasi dari sel otot jantung. Hasil penelitian ini menunjukkan bahwa tidak terdapat tikus yang mati akibat pemberian EKP, akan tetapi terdapat kerusakan ringan pada dosis EKP 250 mg/KgBB, kerusakan sedang pada dosis EKP 500 mg/KgBB, kerusakan sedang-berat pada dosis EKP 750mg/KgBB dan kerusakan berat pada dosis EKP 2000 mg/KgBB. Berdasarkan hasil penelitian ini, maka dapat disimpulkan bahwa kerusakan sel otot jantung meningkat secara signifikan seiring dengan peningkatan dosis ekstrak etanol rimpang kunyit putih dimana kerusakan sel otot jantung terberat pada dosis EKP 2000mg/kgBB.Kata kunci : jantung; kunyit putih; tikus. AbstractWhite turmeric (Curcuma zedoaria) is a herbal plant that is widely used as herbal medicine in Asia because of its properties which are believed to increase the body’s immune system, anti-inflammatory, and an analgesic. The use of herbal medicine is generally believed by the public to have lower side effects than modern medicine, but in reality, there has not been much research on the side effects of white turmeric usage. The novelty in this study was due to the acute study of white turmeric extract on the histopathological analysis of heart muscle. Therefore, this study aims to determine the acute toxicity of white turmeric’s rhizome ethanol extract on histopathological features of the heart muscle. This experiment used 30 male white Wistar rats (Rattus norvegicus) with a weight between 150-200 grams. Rats were divided into 2 control groups and 4 groups of treatment. Treatment given to the rats are aquadest, NaCMC 1% WTE 250mg/KgBW, WTE 500mg/KgBW, WTE 750mg/KgBW, and WTE 2000mg/KgBW . The parameters observed are hyperemia, hemorrhage, and degeneration of heart muscle cells. The result showed in this study were that there were no mice that died due to EKP administration, but there was mild damage at WTE dose of 250 mg/KgBB, moderate damage at WTE dose of 500 mg/KgBB, moderate-severe damage at WTE dose of 750mg/KgBB and severe damage on WTE dose of 2000 mg/KgBW. Based on the results of this research, it can be concluded that there is significant damage found along with an increasing dose of white turmeric extract given, where the damage on heart muscle cells is most severe at WTE dose of 2000 mg/KgBW.

Cystatin C is a 13 kD molecular-weight protein synthesized by all nucleated cells which functions as a cysteine protease inhibitor. Cystatin C is detectable when kidney function decreases due to the excessive accumulation of nephrotoxic substances such as copper. Previous studies have proven that, white turmeric rhizome can act as a nephroprotector agent at a dose of 500 mg/BW. The purpose of this study is compare Cystatin-C marker and serum creatinine as biomarkers in the examination of acute kidney injuries induced by nephrotoxic substance. This was a post-test only controlled experimental study on wistar strain male rats that were divided randomly using simple random sampling approach into three groups; normal control group, treatment control group (Curcumin for 2 weeks followed by CuSO4 for 3 days at each weekend), and CuSO4 pentahydrate control group. This research is conducted at Faculty of Pharmacy and Faculty of Medicine at the University of North Sumatera in May to August 2019. The analysis results is normally distributed and has significant differences in levels of Cystatin-C, creatinine and protein serum due to differences in the treatment of each group where p<0.05. Serum Cystatin-C as a biomarker in this study shows more sensitive in detecting acute kidney damage compared to serum creatinine.

Pendahuluan: Diabetes dan obesitas adalah masalah kesehatan yang dapat mempengaruhi kehidupan manusia dari segi kesehatan, sosial dan ekonomi. Komplikasi yang diakibatkan oleh diabetes diantaranya adalah gangguan metabolism dan nefropati diabetikum. Rimpang kunyit putih (Curcuma zedoaria) memiliki manfaat diantaranya sebagai antioksidan, antiinflamasi, antiproliferasi, antikanker, dan antimikroba. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak rimpang kunyit putih terhadap lipid darah pada tikus wistar dengan nefropati diabetikum. Metode: Penelitian ini adalah penelitian eksperimental dengan rancangan the post-test only control group design. Penelitian dilakukan di Laboratorium Farmakolgi Fakultas Farmasi USU, Laboratorium Histologi Fakultas Kedokteran USU, dan Laboratorium Biomolekuler Fakultas Kedokteran UNPRI pada bulan April-Juli 2020. Hasil: Tikus putih jantan galur wistar dibagi menjadi enam kelompok; yaitu kelompok kontrol normal (P1), kelompok kontrol negatif (P2), kelompok kontrol positif (P3), tiga kelompok perlakuan dengan kunyit putih masing-masing dengan dosis P4=100, P5=200, P6=400 mg/kgBB yang sebelumnya telah diberi diinduksi aloksan. Data dianalisis menggunakan uji One Way Anova. Terdapat perbedaan yang signifikan pada ekstrak dengan dosis 100mg/kgbb dibandingkan dengan kelompok yang lain. Kesimpulan: Dapat disimpulkan ekstrak kunyit putih dapat menstabilkan kadar kolesterol dan trigliserida serum pada tikus model diabetes nefropati.

Gastroesophageal reflux disease (GERD) is defined as a gastrointestinal motility disorder caused by the reflux of gastric contents into the esophagus or oral cavity. This results in symptoms or complications if persistent, resulting in a significant reduction in quality of life and morbidity. Several studies have reported an association between nocturnal GERD and sleep disturbances, which can significantly affect the quality of life. This study explores the relationship between sleep quality and the incidence of GERD in clinical clerkship students at the Faculty of Medicine, Universitas Prima Indonesia. This study is a cross-sectional observational study involving 144 clinical clerkship students. The GERDQ was used to diagnose GERD, and the PSQI questionnaire was used to measure sleep quality. Respondents who did not suffer from GERD with good sleep quality were 32 respondents (22.2%). Those who did not suffer from GERD with poor sleep quality were 65 respondents (74.8%), who suffered from GERD with good sleep quality only 1 respondent (10, 8), and 46 respondents (36.2%). There is a significant relationship between sleep quality and GERD in clinical clerkship students at the Faculty of Medicine, Universitas Prima Indonesia.

Liver cirrhosis is the result or complication of a chronic liver condition where the liver parenchyma is damaged so that its function decreases. This study aims to study the profile of patients with liver cirrhosis at the Imelda Pekerja Indonesia General Hospital in Medan for the period January 2020 - December 2021. This study is a descriptive observational study. A total of 40 samples of medical records of patients with a diagnosis of liver cirrhosis at the Imelda Pekerja Indonesia General Hospital in (IPI) Medan were included in this study. Univariate analysis in the form of frequency distribution data tabulation was used to present the data. The results showed that most patients with liver cirrhosis were male (72.5%), aged 56-65 years (32.5%), and the main complaint was nausea and vomiting (47.5%). The most physical examination results were ascites (52.5%), abnormal lab results were increased SGPT (75%), SGOT (80%), total bilirubin (85%), prothrombin time (75%) and decreased albumin (85%) and Hb (55%), most of the patients were in the category of Child-Pugh Score B (37.5%) and C (37.5%), and the most complication was hepatorenal syndrome (55%). In conclusion, the profiles of patients with liver cirrhosis are mostly male, aged 56-65 years, with the most complaints of nausea and vomiting and the most physical examination findings of ascites. There was an increase in SGPT, SGOT, total bilirubin, and prothrombin time, as well as a decrease in albumin and Hb.