IntroductionStarting in December 2021, the Indonesian Government has recommended inactivated SARS-CoV-2 vaccine (CoronaVac) for children aged 6–11 years. This study aims to determine the prevalence and determinant factors of adverse events following immunization (AEFI) of the first dose and the second dose of the COVID-19 vaccine among children aged 6–11 years old.Materials and methodsWe conducted a cross-sectional study in Bantul District, Yogyakarta, Indonesia, in February–March 2022. Data were collected by trained interviews with 1,093 parents of children 6–11 years old who received the first dose and the second dose of the COVID-19 vaccine. Data were analyzed with chi-square and logistic regression.ResultsThe prevalence of AEFI in the first dose of the COVID-19 vaccine was 16.7%, while the second dose was 22.6%. The most common symptoms of AEFI at the first dose were local site pain and fever, while at the second dose were cough and cold. Determinants of AEFI of COVID-19 vaccination among children were girls with OR 1.31 (95% CI 1.0–1.7; P 0.04), mass-setting of vaccination with OR 0.70 (95% CI 0.5–0.9; P 0.01), the history of AEFI in childhood vaccination with OR 1.63 (95% CI 1.2–2.2; P < 0.01) and administering other vaccines within 1 month before COVID-19 vaccination, with OR 5.10 (95% CI 2.1–12.3 P < 0.01).ConclusionThe prevalence of AEFI in the first and the second dose of inactivated COVID-19 vaccine was comparable to that reported in the clinical trial study and the communities. Risk communication should be provided to the child and their parents regarding the risk of mild AEFI of the COVID-19 vaccine, especially for children with a history of AEFI in childhood vaccination and who received other vaccines containing the same adjuvant with CoronaVac within 1 month. A mass-setting of vaccination should be taken as an advantage to educate parents about the risk of AEFI and also about the reporting pathways.

Dampak signifikan dari co-sirkulasi virus dengue dengan COVID-19 pada sistem kekebalan tubuh. Pengetahuan mengenai tanda-tanda awal / gejala klinis kasus dapat membantu mencegah terjadinya keparahan penyakit yang lebih berat karena terjadi koinfeksi. Penemuan kasus COVID-19 di  wilayah endemis DBD pun sering terjadi. Pembatasan jarak sosial sebagai pencegahan penularan COVID-19, dapat berdampak pada kejadian DBD. Tujuan dilakukannya penelitian ini untuk mendapat gambaran ekologi vektor Demam Berdarah Dengue dalam penelusuran kasus Covid-19 di wilayah endemis DBD. Penelitian dilaksanakan daerah Kota Temanggung yang termasuk wilayah endemis DBD.  Penelitian dilaksanakan dengan desain observasi analitik. Responden dipilih berdasarkan kriteria tertentu. Deskripsi ekologi vektor DBD didapat dengan menganalisa data sekunder serta primer dalam penelusuran kasus Covid-19 di daerah endemis DBD di Kota Temanggung. Hasil penelitian menunjukkan bentuk topografi cekungan atau depresi mendominasi  wilayah Kabupaten Temanggung. Daerah berbentuk pegunungan dan bukit dengan wilayah dataran lebih rendah dibagian tengah. Kejadian DBD maupun Covid-19 lebih banyak terjadi pada lahan pemukiman daripada lahan lainnya. Hal ini dapat dipengaruhi oleh kepadatan penduduk, kebersihan lingkungan, aktivitas warga.  Ditemukan ada 7 wilayah kerja puskesmas di Kabupaten Temanggung terdapat kasus Covid-19 dengan riwayat DD dan DBD. Dominasi penderita DBD sebanyak 84,49%  berada di wilayah dengan status endemis di tingkat desa maupun kelurahan. Sebanyak 7 kecamatan berstatus wilayah endemik ditemukan  kasus Covid-19 dengan riwayat pernah positif DBD dan DD.