Background: Waldenström’s macroglobulinemia may be complicated by retinal hemorrhages, retinal vein occlusion, serous macular detachment or macular edema. We report a patient with pseudovitelliform subfoveal deposit complicating Waldenström’s macroglobulinemia. Case Report: A 56-year-old man presented with hyperviscosity syndrome due to Waldenström’s macroglobulinemia. After systemic therapy, a large serous retinal detachment persisted in the left eye. A pseudovitelliform subfoveal deposit was observed in the right eye. Conclusion: Pseudovitelliform subfoveal deposits may be part of the spectrum of ocular complications in Waldenström’s macroglobulinemia. They could be due to accumulation of macroglobulins.