Pseudovitelliform Subfoveal Deposit in Waldenström’s Macroglobulinemia

Abstract

Background: Waldenström’s macroglobulinemia may be complicated by retinal hemorrhages, retinal vein occlusion, serous macular detachment or macular edema. We report a patient with pseudovitelliform subfoveal deposit complicating Waldenström’s macroglobulinemia. Case Report: A 56-year-old man presented with hyperviscosity syndrome due to Waldenström’s macroglobulinemia. After systemic therapy, a large serous retinal detachment persisted in the left eye. A pseudovitelliform subfoveal deposit was observed in the right eye. Conclusion: Pseudovitelliform subfoveal deposits may be part of the spectrum of ocular complications in Waldenström’s macroglobulinemia. They could be due to accumulation of macroglobulins.

Atypical White Dot Syndrome in an Older Man

“…Intraretinal and subretinal IgM deposits have also been detected, although definitive identification of IgM would require biopsy. In light of the entire clinical and laboratory picture, subretinal deposits are presumed to be IgM collections as was true for this patient . Others have reported a paraneoplastic retinopathy resulting in photoreceptor dysfunction detectable on electroretinogram .…”

“…In light of the entire clinical and laboratory picture, subretinal deposits are presumed to be IgM collections as was true for this patient. 3,[6][7][8] Others have reported a paraneoplastic retinopathy resulting in photoreceptor dysfunction detectable on electroretinogram. 1 Waldenström macroglobulinemia can rarely manifest as secondary orbital cellulitis from increased susceptibility to infection due to relative agammaglobulinemia.…”

Localized retinal degeneration secondary to Waldenström's macroglobulinemia

“…Brolly et al . [ 6 ] have reported a similar case wherein they have postulated the subretinal deposits to be caused by the accumulation of immunoglobulins. Friedman et al .…”