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RÉSUMÉ La spectrométrie d'émission en plasma induit couplée à la spectrométrie de masse (ICP-MS) est MOTS-CLÉS

Résumé - Mots clés : Oxycyanure de mercure, intoxication aiguë, cheveux, ICP-MSAbstract -Mercury determination in blood, urine and hair following mercuric oxycyanide poisoning. Case report: A 53-year old pharmacist is admitted to hospital after poisoning with a magistral formulation containing mercuric oxycyanide. The initial treatment consists of the administration of hydroxocobalamine and dimercaprol (BAL), followed by a blood purifying treatment, hemodialysis, then dimercaptosuccinic acid (DMSA) and hemoperfusion. Material and methods: Mercury is quantified using cold vapor -atomic absorption spectrometry (CV-AAS) in blood and ICP-MS in urine. The mercury concentrations, determined in blood and urine 24 hours after ingestion were respectively 3087 μg/L (reference value < 5 μg/L) and 9573 μg/g creatinin (reference value < 3 μg/g). Mercury was quantified in blood and urine during 52 days of hospitalisation to follow its excretion and treatments efficiency. A mercury quantification is carried out using ICP-MS on two locks of hair collected two months after ingestion. Hair specimen (6 cm) was cut into six equal lengths. Results and discussion: Mercury concentrations range from 4.6 to 41.2 ng/mg (reference value < 1 ng/mg). These high concentrations could be explained by a contamination of the hair by sebum.