MethodsSolvent dispersion: An equivalent quantity of β-cyclodextrin and ammonia, were heated in a water bath at 100°C. Eventually the indomethacin was added to the complex and kept under AbstractThe objective of present work was to compare the effect of different solubility enhancement methods like solvent dispersion, physical mixture, hydrotropy, solid dispersion and freeze drying on in-vitro release and stability studies of indomethacin. Indomethacin, BCS class II NSAIDs, acts by inhibiting COX-I and II enzymes and uses in treating various conditions like rheumatoid arthritis, pain and headache. Inclusion complex formulations were prepared using different methods like solvent dispersion, physical mixing, hydrotropy, solid dispersion and freeze drying. Particle size and zeta potential observed varied range of values between 479.4±1.12 to 1417±2.37nm and in between -15.3±1.08 to -24.9±1.18mV respectively. The highest solubility was observed in solid dispersion due to highest reduction of particle size. In-vitro drug release study showed controlled indomethacin release pattern in solid dispersion for 24 h as compared to other inclusion complexes. Solid dispersion method emphasizes its importance in enhancing the solubility and bioavailability, controlled release and stability of indomethacin.