Owing to their mechanical properties, metallic materials present a promising solution in the field of resorbable implants. The magnesium metabolism in humans differs depending on its introduction. The natural, oral administration of magnesium via, for example, food, essentially leads to an intracellular enrichment of Mg(2+) . In contrast, introducing magnesium-rich substances or implants into the tissue results in a different decomposition behavior. Here, exposing magnesium to artificial body electrolytes resulted in the formation of the following products: magnesium hydroxide, magnesium oxide, and magnesium chloride, as well as calcium and magnesium apatites. Moreover, it can be assumed that Mg(2+) , OH(-) ions, and gaseous hydrogen are also present and result from the reaction for magnesium in an aqueous environment. With the aid of physiological metabolic processes, the organism succeeds in either excreting the above mentioned products or integrating them into the natural metabolic process. Only a burst release of these products is to be considered a problem. A multitude of general tissue effects and responses from the Mg's degradation products is considered within this review, which is not targeting specific implant classes. Furthermore, common alloying elements of magnesium and their hazardous potential in vivo are taken into account.

Despite the availability of surgical and non‐surgical techniques, the repair of articular cartilage lesions remains a current clinical problem. Especially for the treatment of large osteochondral cartilage defects, the replacement of the subchondral bone plate is a crucial step for optimal cartilage repair. However, no artificial implant material can yet fully restore the properties of the subchondral bone plate. For optimal cartilage tissue repair, mechanical stability for the first two months is essential. Subsequently, a rapid degradation process of the implant material would allow optimal supply of nutrition to the regenerating tissue. To this end, we investigated whether the implantation of an open porous degradable scaffold made of a magnesium alloy (AZ91) could serve as a sufficient temporary replacement of the subchondral bone plate. The results show that this alloy degrades too rapid in vivo to allow sufficient cartilage repair above the scaffold. However, the surrounding cartilage tissue was not negatively affected by the rapid degradation process and new bone formation was observed at the rim of the degrading implant. In conclusion, magnesium scaffolds degrade in vivo but the initial high corrosion rate must be reduced to allow the formation of an appropriate cartilage tissue. Future research will therefore be directed to optimized alloys and additional coating with magnesium fluorides or calcium phosphates like hydroxyapatite.

Biofilm formation on oral implants can cause inflammation of peri-implant tissues, which endangers the long-term success of osseointegrated implants. It has been reported previously that implants revealing signs of peri-implantitis contain subgingival microbiota similar to those of natural teeth with periodontitis. The purpose of the first part of this study was an atraumatic, quantitative investigation of biofilm formation on oral implant abutments; the objective of the second part was to investigate whether Haemophilus actinomycetemcomitans and Porphyromonas gingivalis were present in the crevicular fluid around oral implants. Biofilm formation on 14 healing abutments, inserted for 14 days in 10 patients, was analysed quantitatively by use of secondary-electron and Rutherford-backscattering-detection methods. A 16S rRNA-based polymerase chain reaction detection method was used to detect the presence of H. actinomycetemcomitans and P. gingivalis in the crevicular fluid. For this investigation, samples of sulcus fluid were collected with sterile paper points at four measurement points per abutment. The difference between biofilm coverage of supragingival surfaces (17.5 +/- 18.3%) and subgingival surfaces (0.8 +/- 1.0%) was statistically significant (P < 0.05). By use of universal primers, bacteria were found in all the samples taken, although the two periodontal pathogens were not found in any of the samples. The absence of periodontal pathogens from the sulcus fluid during initial bacterial colonization, despite massive supragingival biofilm formation, substantiates the assumption that cellular adherence of peri-implant tissue by means of hemidesmosoma, actin filaments and microvilli reduces the risk of formation of anaerobic subgingival pockets.

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Apart from reducing the processing energy, hardening and tempering of near-net shape forged components from their forging heat primarily promises shortened conventional process sequences. In this case, the continuous cooling transformation diagrams (CCT diagrams) found in the literature can only be used as a rough approximation of microstructural transformations during the heat-treatment. The reasons for this are that firstly, the deformation influences the transformation kinetics and secondly, the deformation temperatures are comparatively high. Therefore, both deformation CCT diagrams and, for reference purposes, CCT diagrams without deformation were determined for a selection of heattreatable steels (34CrMo4, 42CrMo4, 52CrMo4, 51CrV4, 34NiMo6) at the heating temperature of 1200 8C and deformation levels of 0.3 and 0.6.