Our study reveals a critical role for monocyte-derived MΦs in restoring intestinal homeostasis after surgical trauma. From a therapeutic point of view, our data indicate that inappropriate targeting of monocytes may increase neutrophil-mediated immunopathology and prolong the clinical outcome of POI, while future therapies should be aimed at enhancing MΦ physiological repair functions.

We challenge the view that our species, Homo sapiens, evolved within a single population and/or region of Africa. The chronology and physical diversity of Pleistocene human fossils suggest that morphologically varied populations pertaining to the H. sapiens clade lived throughout Africa. Similarly, the African archaeological record demonstrates the polycentric origin and persistence of regionally distinct Pleistocene material culture in a variety of paleoecological settings. Genetic studies also indicate that present-day population structure within Africa extends to deep times, paralleling a paleoenvironmental record of shifting and fractured habitable zones. We argue that these fields support an emerging view of a highly structured African prehistory that should be considered in human evolutionary inferences, prompting new interpretations, questions, and interdisciplinary research directions.The lineage of Homo sapiens probably originated in Africa at least 500 thousand years ago (ka) [1], and the earliest observed morphological manifestations of this clade appeared by 300 ka [2]. Early H. sapiens fossils do not demonstrate a simple linear progression towards contemporary human morphology. Instead, putative early H. sapiens remains exhibit remarkable morphological diversity and geographical spread. Together with recent archaeological and genetic lines of evidence, these data are consistent with the view that our species originated and diversified within strongly subdivided (i.e., structured) populations, probably living across Africa, that were connected by sporadic gene flow [1,3-8]. This concept of 'African multiregionalism' [1] may also include hybridization between H. sapiens and more divergent hominins (see Glossary) living in different regions [1,[9][10][11][12]. Crucially, such population subdivisions may have been shaped and sustained by shifts in ecological boundaries [7,13,14], challenging the view that our species was endemic to a single region or habitat, and implying an often underacknowledged complexity to our African origins.In this paper we examine and synthesize fossil, archaeological, genetic, and paleoenvironmental data to refine our understanding of the time-depth, character, and maintenance of Pleistocene population structure. In doing so, we attempt to separate data from inference to stress that using models of population structure fundamentally changes interpretations of recent human evolution. HighlightsThe view that Homo sapiens evolved from a single region/population within Africa has been given primacy in studies of human evolution.The constellation of morphological features characterizing H. sapiens is debated. This has strongly impacted on interpretations of recent human origins by variably including or excluding different fossils from interpretative analyses. For example, different morphological criteria and analytical methods have been used to support both a gradual, mosaic-like process of modernization of our species or, conversely, a punctuated speciation (e.g., [1]).Extant human...

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenopathy (PFAPA) syndrome is a mysterious disorder characterized by periodically recurrent fevers, oropharyngeal inflammation, and adenitis, which mainly affects children, though in very recent times, it has been also recognized in adulthood. We enrolled 115 unrelated pediatric and adult patients with history of periodic fevers who fulfilled the current diagnostic criteria for PFAPA syndrome in three Italian referral centers and highlighted differences between children and adults. Eighty-five children and 30 adults were evaluated: the frequency of flares was significantly higher in pediatric cases, while febrile attack duration was significantly longer in adults. Clockwork periodicity of fever and recurrent pharyngitis were more frequently observed in childhood, but no differences were identified for aphthosis and cervical adenopathy. Conversely, joint symptoms, myalgia, headache, fatigue, ocular signs, and rashes were more common in adults. The simultaneous occurrence of two or three cardinal PFAPA signs did not show any statistical difference between the groups, while the occurrence of only one cardinal manifestation was more frequent in adults. Corticosteroids were effective in 98.82 % of children and 88.2 % of adults. Tonsillectomy was rarely performed, resulting effective in only two patients. Our data illustrate the clinical overlap between pediatric and adult cases of PFAPA syndrome. Adults are characterized by a wider repertoire of inflammatory signs, suggesting that onset in adulthood might leave the disease misdiagnosed. Clinicians, not only pediatricians, should take into account this clinical entity in every patient of whatever age suffering from recurrent fevers of unknown origin.

Abstract. The exploration of how we react to the world and interact with it and each other remains one of the greatest scientific challenges. Latest research trends in cognitive sciences argue that our common view of intelligence is too narrow, ignoring a crucial range of abilities that matter immensely for how people do in life. This range of abilities is called social intelligence and includes the ability to express and recognise social signals produced during social interactions like agreement, politeness, empathy, friendliness, conflict, etc., coupled with the ability to manage them in order to get along well with others while winning their cooperation. Social Signal Processing (SSP) is the new research domain that aims at understanding and modelling social interactions (human-science goals), and at providing computers with similar abilities in human-computer interaction scenarios (technological goals). SSP is in its infancy, and the journey towards artificial social intelligence and socially-aware computing is still long. This research agenda is a twofold, a discussion about how the field is understood by people who are currently active in it and a discussion about issues that the researchers in this formative field face.

Purpose The purpose of this paper is to explore the “dark nuances” of social media by identifying moral disengagement (MD) mechanisms and hostile emotions in people discussing the hosting of immigrants and examining the relationship between MD mechanisms and hostile emotions expressed online (annoyance, irritation and contempt). Design/methodology/approach The method was based on a psycho-lexicographical approach that analysed the in vivo real words, adopting a quanti-qualitative point of view. The investigation started from the case of a Facebook post in support of immigrants after a serious shipwreck causing the death of more than 700 would-be migrants. More than 10,000 comments were codified. For the comments against the hosting of such immigrants, the authors followed a codebook aimed at identifying MD mechanisms and hostile emotions. Findings The main findings show an interplay between different hostile negative emotions and online MD mechanisms. The greater the intensity of hostile emotions, the more the locus of disengagement moves from the unethical individual’s behaviour – for example, offering moral justifications – to the target recipient of such behaviour – for example, blaming or dehumanising. Practical implications The study could be applicable in designing and developing algorithms and technological tools aimed at preventive interventions to promote moral awareness and emotional regulation in online settings. Social implications The study may be a useful contribution to understanding unethical orientation by identifying areas where education can intervene in reducing harmful behavioural tendencies. Originality/value This study takes together expressed hostile emotions and MD mechanisms by means of the analysis of real words in vivo through social media discussions.