The continuously growing number of objects orbiting around the Earth is expected to be accompanied by an increasing frequency of objects re-entering the Earth’s atmosphere. Many of these re-entries will be uncontrolled, making their prediction challenging and subject to several uncertainties. Traditionally, re-entry predictions are based on the propagation of the object’s dynamics using state-of-the-art modelling techniques for the forces acting on the object. However, modelling errors, particularly related to the prediction of atmospheric drag, may result in poor prediction accuracies. In this context, we explored the possibility of performing a paradigm shift, from a physics-based approach to a data-driven approach. To this aim, we present the development of a deep learning model for the re-entry prediction of uncontrolled objects in Low Earth Orbit (LEO). The model is based on a modified version of the Sequence-to-Sequence architecture and is trained on the average altitude profile as derived from a set of Two-Line Element (TLE) data of over 400 bodies. The novelty of the work consists in introducing in the deep learning model, alongside the average altitude, and three new input features: a drag-like coefficient (B*), the average solar index, and the area-to-mass ratio of the object. The developed model was tested on a set of objects studied in the Inter-Agency Space Debris Coordination Committee (IADC) campaigns. The results show that the best performances are obtained on bodies characterised by the same drag-like coefficient and eccentricity distribution as the training set.