Herein, the isolation of secondary metabolites from the aerial parts of Justicia aequilabris guided by HPLC-MS n and molecular networking analyses is reported. Twenty-two known compounds were dereplicated. Three new lignans (aequilabrines A− C (1−3)) and three known compounds (lariciresinol-4′-O-β-glucose (4), roseoside (5), and allantoin (6)) were obtained. The antiinflammatory activity of compounds 1−3 was evaluated in vitro by inhibiting the nitric oxide production (NO) and proinflammatory activity on the cytokine IL-1β. Compounds 2 and 3 showed significant inhibitory activity against NO production, with IC 50 values of 9.1 and 7.3 μM, respectively. The maximum inhibition of IL-1β production was 23.5% (1), 27.3% (2), and 32.5% (3).

Mandevilla Lindl. is an important genus of the Apocynaceae family, not only as ornamental plants but also for its medicinal uses. In Brazil, Mandevilla species are indicated to treat asthma and skin infections, their anti-inflammatory potential and wound healing properties are also reported in the literature. Concerning their chemical composition, this group of plants is a conspicuous producer of pregnane glycosides. Mandevilla dardanoi is an endemic species from the Brazilian semiarid region not studied by any phytochemical methods. In view of the medicinal potential of Mandevilla species, this study aimed to isolate new pregnane glycosides from M. dardanoi. To achieve this main goal, modern chromatography techniques were employed. Five new pregnane glycosides, dardanols A-E, were isolated from the roots of M. dardanoi by HPLC. Their structures were determined using extensive 1D and 2D-NMR and mass spectrometry (MSn and HRESIMS) data. The cytotoxicity and the anti-inflammatory potential of these compounds were evaluated. The first was evaluated by measuring proinflammatory cytokines and nitric oxide production by stimulated macrophages. Dardanols were able to inhibit the production of nitric oxide and reduce IL-1β and TNF-α. The current work demonstrates the chemodiversity of Brazilian semiarid species and contributes to amplifying knowledge about the biological potential of the Mandevilla genus.

The aim of this study was to obtain bioactive compounds from Mandevilla dardonoi (Apocynaceae), in order to contribute positively to the discovery of new sources of active natural substances. Based on this, the compounds obtained from the ethyl acetate phase were isolated by medium pressure column chromatography and high performance liquid chromatography and identified by nuclear magnetic resonance (1 H) and electrospray mass spectrometry. It was possible to isolate 6 chlorogenic acids: 3-caffeoylquinic (3-ACQ), 4-caffeoylquinic (4-ACQ), 5-caffeoylquinic (5-ACQ), 3,4-dicaffeoylquinic 4-diACQ), 3,5dicaffeoylquinic (3,5-diACQ) and 4,5dicaffeoylquinic (4,5-diACQ) acids. The research contributed positively to the expansion of the knowledge about the genus Mandevilla and especially of the species M. dardonoi, which did not exist reports of phytochemical studies in the literature.

The aim of this study was to obtain bioactive compounds from Mandevilla dardonoi (Apocynaceae), in order to contribute positively to the discovery of new sources of active natural substances. Based on this, the compounds obtained from the ethyl acetate phase were isolated by medium pressure column chromatography and high performance liquid chromatography and identified by nuclear magnetic resonance ( 1 H) and electrospray mass spectrometry. It was possible to isolate 6 chlorogenic acids: 3-caffeoylquinic (3-ACQ), 4-caffeoylquinic (4-ACQ), 5-caffeoylquinic (5-ACQ), 3,4-dicaffeoylquinic 4-diACQ), 3,5dicaffeoylquinic (3,5-diACQ) and 4,5dicaffeoylquinic (4,5-diACQ) acids. The research contributed positively to the expansion of the knowledge about the genus Mandevilla and especially of the species M. dardonoi, which did not exist reports of phytochemical studies in the literature.

Atuação do enfermeiro a gestantes portadoras de síndrome hipertensiva na atenção básicaNurse's performance to pregnant women with hypertensive syndrome in primary care RESUMO Introdução: A Síndrome Hipertensiva Específica da Gestação (SHEG) é uma patologia obstétrica que merece grande atenção dos profissionais de saúde. Surge após a 20ª semana de gestação, mais frequente no terceiro trimestre, e se desenvolve até o puerpério. As principais características são hipertensão arterial, edema e/ou proteinúria. Objetivo: Identificar os cuidados de enfermagem prestados à gestante com Emergências Hipertensivas na Atenção Primária. Metodologia: Estudo descritivoexploratório, do tipo revisão integrativa da literatura. A busca bibliográfica ocorreu por meio da seleção de artigos científicos selecionados e publicados em periódicos na Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS); Base de Dados em Enfermagem (BDENF); Google acadêmico; Brasil Scientific Electronic Library Online (SciELO); e a Biblioteca Virtual de Saúde (BVS), utilizando os descritores: Hipertensão arterial; Gestação; Cuidados de Enfermagem. Resultados:As unidades básicas de saúde são a porta de entrada da gestante, para avaliação de fatores de riscos que predispõe a SHEG, estando o enfermeiro em evidência, capaz de intervir de maneira positiva no processo. Conclusão: As complicações de saúde que cercam o processo gestacional podem ocasionar comprometimentos de nível sistêmico interferindo diretamente no cotidiano do binômio mãe e filho. A SHEG, como uma destas complicações, possui uma prevalência considerável, com alta letalidade, mesmo diagnosticada precocemente. O enfermeiro é essencial para promover prevenção e intervenções, como orientações sobre medicações, atividades físicas, cuidados com sinais vitais e dieta, além de encaminhamentos a centros especializados.