Introduction. The major medical concern with giant congenital melanocytic nevi CMN is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanocytosis. Case Report. A 30-year-old woman with a giant congenital melanocytic nevus covering nearly the entire right thoracodorsal region and multiple disseminated melanocytic nevi presented with neurological symptoms. Cerebral magnetic resonance imaging revealed a large expansive lesion in the left frontal region. Postsurgically pathological diagnosis revealed characteristics of melanoma. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+). She received radiotherapy with temozolomide followed by two more chemotherapy cycles with temozolomide. She followed a rapidly progressive course, reflecting widespread leptomeningeal infiltration, and she died of multiorgan failure seven months after diagnosis of cerebral melanoma. Discussion. This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.

Esta investigação centra-se na análise do culto à Imaculada Conceição, por parte da Corte portuguesa, na igreja de Vila Viçosa, nos reinados de D. Pedro II e D. João V. Interessou-nos averiguar se as ofertas da família real e da nobreza à Padroeira de Portugal, através da Régia Confraria de Nossa Senhora da Conceição, tinham relevância para o seu culto. As principais fontes utilizadas no nosso estudo foram os inventários de bens da confraria, elaborados em 1679 e 1719. A análise da documentação revelou um considerável número de joias e de objetos de culto oferecidos à Padroeira de Portugal, confirmando, deste modo, a igreja como um espaço devocional de relevância.

Este artigo aborda a devoção das religiosas dos conventos das Chagas, de Santa Cruz e da Esperança a Nossa Senhora da Conceição de Vila Viçosa, padroeira de Portugal. Inscritas na Irmandade dos Escravos, fizeram a ponte entre a igreja matriz e os meios claustrais mais nobres da localidade. PALAVRAS-CHAVE: Nossa Senhora da Conceição. Conventos. Irmandade.

The devotion to the Immaculate Conception in Vila Viçosareassembles to the Middle Age. With the establishment of House of Braganza in the locality, was extremely estimated by the ducal family. The party, organized by the Brotherhood of Our Lady of Conception, included a Eucharistic celebration, a monumental procession, and other profane amusements, including bullfights and fireworks. The study of this 17th century celebration focuses on the account of António de Oliveira de Cadornega is cross-checked with brotherhood documentation and with other historiography

In 1646, Our Lady of Conception of Vila Viçosa was proclaimed patroness of Portugal by king John IV. The liturgical service to the patroness was made by the Régia Confraria de Nossa Senhora da Conceição, which had big incomes. A small portion was allocated to alms, both in wheat and in money. The main beneficiaries were women widows and orphans, although confreres of brotherhood and some convents were also contemplated.