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A novel fabrication process called BETTS (bonding, UV exposing and transferring technique in SU-8) is presented in this paper. SU-8 layers can be transferred and patterned over SU-8 microstructures by means of a removable, flexible and transparent substrate. This substrate is composed of a thin acetate film, which can be also used as a mask, and a cured PDMS layer deposited over it. SU-8 is then spin coated and transferred to the SU-8 structures performing simultaneously the steps of bonding and transferring by UV exposure. Due to the low adhesion between PDMS and SU-8, acetate film removal can be easily performed. BETTS provides easy, irreversible and robust SU-8 to SU-8 bonding, where the absence of oxygen plasma equipment or vacuum systems decreases drastically the fabrication cost and time involved. The reported fabrication process makes it possible to fabricate complex SU-8 three-dimensional structures using a simple and inexpensive procedure and also ensures its compatibility and integration with microfluidic and PCB-MEMS devices. Some specific applications such as multilevel microchannel network, patterned membranes, microchambers and microvalves are reported to demonstrate the potential of the proposed process.

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Lab-on-PCB devices have been developed for many biomedical and biochemical applications. However, much work has to be done towards commercial applications. Even so, the research on devices of this kind is rapidly increasing. The reason for this lies in the great potential of lab-on-PCB devices to provide marketable devices. This review describes the active flow driving methods for lab-on-PCB devices, while commenting on their main characteristics. Among others, the methods described are the typical external impulsion devices, that is, syringe or peristaltic pumps; pressurized microchambers for precise displacement of liquid samples; electrowetting on dielectrics; and electroosmotic and phase-change-based flow driving, to name a few. In general, there is not a perfect method because all of them have drawbacks. The main problems with regard to marketable devices are the complex fabrication processes, the integration of many materials, the sealing process, and the use of many facilities for the PCB-chips. The larger the numbers of integrated sensors and actuators in the PCB-chip, the more complex the fabrication. In addition, the flow driving-integrated devices increase that difficulty. Moreover, the biological applications are demanding. They require transparency, biocompatibility, and specific ambient conditions. All the problems have to be solved when trying to reach repetitiveness and reliability, for both the fabrication process and the working of the lab-on-PCB, including the flow driving system.

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