No abstract

one of the most striking processes of cell sheet folding: Through inwards folding at the equator of the initially spherical cell sheet adopts a mushroom shape and eventually turns itself entirely inside-out through an anterior opening [1]. These global deformations are driven by several waves of active cell shape changes [2, 3]. A combination of advanced imaging and computational analyses is used to explore the role of tissue contractility in the occurring invagination and involution. The associated internal stresses as well as the elastic properties of the dynamic cell sheet are determined through laser ablation experiments [manuscript in preparation].

The purpose of this work is to calculate the deformation undergone by a cell in function of its nucleus size and mechanical properties. The cell immersed in a fluid go through a variable section channel and it is deformed by fluid forces.Cell deformation into the channel causes changes at the fluid velocity profile. This fluid configuration change results in diferent normal and viscous forces around the cell. Due to strong correlation between cell deformation and fluid velocity profile, a fluidsolid interacción (FSI) is required.