No abstract

Both in linear T2 DNA, analyyzed by velocity sedimentation, and in supercoiled Col EL DNA, analyzed by gel electrophoresis, the number of double-strand breaks produced by bleomycin was directly propotional to the number of single-strand breaks and was far greater than the number expected from random coincidence of single-strand breaks, suggesting that the bleomycin-induced double-strand breaks occur as an independent event. In Col EL DNA, at least twice as many single-strand breaks were found under alkaline assay conditions as were found under neutral conditions, showing the production of alkaline-labile bonds by bleomycin.

No abstract

The compound 5-bromouracil (BrU) may be incorporated into DNA in place of its analog thymine. This review is concerned with the photochemical lesions produced by the action of ultraviolet light on such BrU-DNA, and consequent biological effects of such lesions.

No abstract