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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The activation of profibrinolysin in sensitized guinea pig serum when mixed in vitro with the homologous antigen was confirmed with a more accurate and more reliable method than the one previously used. A study was made of some of the conditions required for obtaining maximum activation. Profibrinolysin activation was also induced in normal guinea pig serum by addition of certain "anaphylactoid" agents such as peptone, tween 20, morphine, octylamine, octadecylamine, and 48/80. The specific antigen and the anaphylactoid agents produce activation only when added to whole, fresh, unheated serum. Profibrinolysin activation by these agents, as opposed to activation by streptokinase, seems to require the intervention of a kinase system (serofibrinokinase) inactivated by fractionation of serum and by heating to 56°C. Whenever serum was submitted to treatments which caused fractionation, fixation or inhibition of complement, serofibrinokinase was also inactivated. Under the conditions investigated the behavior of this kinase was indistinguishable from that of complement.

The metabolic disposal of epinephrine and related amines is usually attributed, in part a t least, to the monoamine oxidase system. This system oxidizes amines to the corresponding aldehydes which then will be converted to the acid. The studies reported in this paper show that the enzyme present in guinea pig liver which converts aromatic aldehydes into the corresponding acids is inhibited reversibly by adrenergic amines and irreversibly by adrenergic blocking agents.Methods. Enzyme activity was measured by means of an ultraviolet spectrophotometric method. Fig. 1 shows that salicylaldehyde, salicylic acid and saligenin ( salicylalcohol ) have distinct absorption peaks in the ultraviolet. The niolar extinction coefficient of salicylaldehyde is 2300 at 325 mp (the peak 250 270 290 310 330 350 F IC: . 1. 1-ltrariolet absorption spectrum of snlicylaldehyde, salicylic acid a i d saligenin, in the presence of trichloracetic atid in proportioils specified in the test. x 1 varclc.iigth in mp; E31 = molar cstinction coeff ici eiit. A ( m r )