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No explanation is offered for the appearance of acrodynia in our experiments in contrast to the usual freedom in mice from acrodynia during pyridoxine deprivation. By inspection of the conditions of previous studies of BG deficient mice together with the variables introduced in our experiments, no definite correlation could be established relating the composition of the diet, age or sex of the mice, the probable pyridoxine content of the diet, levels of other vitamins, etc., to the protection from, or appearance of, acrodynia. The syndrome has appeared in the mice without fail on 3 different occasions that were so spaced in time (February, May, and September) that suclh factors as season and humidity were prob-was tested, and it may be that strain differences play an important role in the appearance of acrodynia.Summary. 1. Pyridoxine deficiency was produced in weanling male and in young adult female mice fed (a) a purified diet containing 9 other crystalline B vitamins, and (b) GL semipurified diet containing a low level of liver powder. 2. Acrodynia appeared among both the weanling and young adult mice fed these 2 diets. 3. As little as 0.166 mg of added crystalline pyridoxine-HC1 per kg of the purified diet protected the mice from acrodynia and resulted in a good growth response by the weanling mice.

Globus hystericus means the "hysterical ball or lump in the throat," and is generally assumed to be of psychic origin. True dysphagia is usually absent. Twelve patients with the globus syndrome were studied at the Esophageal Motility Laboratory of the Saint Luke's Hospital of Cleveland. An organic cause for their symptomatology was ruled out by physical examination, laryngoscopy, esophagoscopy and cineesophagograms. Ten patients showed significant elevations in esophageal resting pressures and nine had evidence of disordered motor activity in the body of the esophagus. Knowing from previous investigations that a suprasternal discomfort may be elicited from stimulation of the esophagus at different levels, we propose that the globus sensation is a referred one coming from the hypertonic and frequently incoordinated body of the esophagus.

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