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Synchronized wide area communication has become a mature technology, which makes the real-time interaction between the substations and the wide area protection and control system possible. However, the present protection and control system to handle this real-time data has been recognized to be deficient. This paper begins by reviewing the development history of power system protection, with special attention paid to the recent development in the field of wide-area and integrated protections, in order to look into the future development of protection and control systems. Then the concept of integrated wide area protection and control is introduced, where it can be shown that a hierarchical protection and control system provides the protection and control for wide area or regional power substations/plants and their associated power networks. The system is mainly divided into three levels: the local, the substation/plant, and the wide area/regional. The integrated functions at each level are described in details with an aim to develop an optimal coordination mechanism between each level. The key element in the proposed system is the wide area real-time protection and control information platform, which not only enables the merger of three lines of defence for power system protection and control, but also provides a perfect tool for the application of cloud computing in substations and power networks.

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Bioeffects after exposure to ultrasound are correlated to its duration. Although diagnostic ultrasound has been suggested to induce apoptosis, the underlying signal transduction pathway remains elusive. In this study, women in the first trimester of pregnancy were exposed to transvaginal diagnostic ultrasound with 5.0-MHz frequency for 0, 10, 20, or 30 min. The chorionic villi were obtained 4 h after exposure and activation of caspase-3 and cytochrome c release were analyzed by Western blotting. In contrast with the 0- and 10-min groups, cleavage products of active caspase-3 and cytochrome c release significantly increased in 20- and 30-min groups in a time-dependent manner. We show that long-duration exposure to transvaginal ultrasound activates effector caspase-3-mediated apoptotic cascade of chorionic villi in the first trimester of pregnancy. This occurs through the intrinsic death pathway involved in cytochrome c release. Our findings provide a molecular rationale for discriminant use of transvaginal ultrasound at the early stage of pregnancy.