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448 Background: Despite advances in multimodality treatment of esophageal squamous cell carcinoma (ESCC), the recurrence rate after curative resection remains high. Assessment of the risk of disease recurrences after curative resection of ESCC will be helpful for optimization of individual patient management. The close association between coagulation status and progression of malignant tumors has been previously reported. We herein sought to identify sensitive prognostic factors in ESCC by combining multiple coagulation markers. Methods: A total of 200 patients who underwent curative subtotal esophagectomy after neoadjuvant treatment for ESCC between January 2012 and December 2020 were included in the analysis. We retrospectively evaluated the correlation of preoperative plasma D-dimer (upper limit of normal, 1.0 μg/mL), fibrinogen (upper limit of normal, 350 mg/dL) levels and the coagulation score, which is calculated by combining levels of D-dimer and fibrinogen, with postoperative prognosis. The coagulation score was determined as follows. 0, neither D-dimer nor fibrinogen were elevated; 1, either D-dimer or fibrinogen was above the upper limit of normal; 2, both were elevated. Results: There was no significant difference in postoperative recurrence-free survival between the high and low groups for either preoperative D-dimer alone or preoperative fibrinogen alone. 59 patients (29.5%), 99 patients (49.5%) and 42 patients (21%) were categorized into coagulation score 0, 1 and 2, respectively. Patients in the coagulation score 1-2 group had a significantly shorter recurrence-free survival time than those in the coagulation score 0 group (hazard ratio 1.99, P = 0.0223). Conclusions: The coagulation score combining with plasma D-dimer and fibrinogen levels was suggested to be a simple predictor of postoperative recurrences in patients undergoing curative subtotal esophagectomy after neoadjuvant treatment for ESCC.

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Introduction: Many previous RCTs comparing single-incision laparoscopic colectomy (SILC) with multiport laparoscopic colectomy (MPLC) have reported that there are no significant differences in the shortterm results between the two types of procedures. However, there are many procedures whose safety and reliability in SILC remain uncertain.Patients and methods: Introduction of our surgical techniques and identification and evaluation of our experience. Retrospective review of the surgical procedures and outcomes of 376 cases of SILC conducted between September 2009 and September 2020.Results: There were at total of 194 men and 182 women, and the median age was 74.0 years. Of the total, 65 patients underwent ileocecal resection, 65 patients underwent right hemicolectomy, 36 patients underwent transverse colectomy, 29 patients underwent left hemicolectomy, 52 patients underwent sigmoidectomy, 99 patients underwent high anterior res ec t ion , 2 9 pat ient s u nder went low a nt er ior resection, and 1 patient underwent abdominoperineal resection. The mean operative time was 227.5 min, and the mean operative blood loss was 5 ml.Clavien-Dindo classification Grade 3 postoperative complications were detected in 14 (3.7％) cases. Discussion: SILC is feasible in patients with colorectal cancer. In terms of the short-term outcomes, SILC is similar to MPLC. Our procedures

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