Editorial on the Research TopicResearch advances in gestational, neonatal diabetes mellitus and metabolic disorders Diabetes mellitus (DM) is among the most common disorders affecting people of all ages across the globe from neonates to seniors (1). Indeed, DM has emerged as one of the major health concerns of this century with a huge economic burden that continues to grow, especially in low and middle-income counties (2). In addition to type 1 and II diabetes (T2DM), gestational diabetes mellitus (GDM) (3) and neonatal diabetes mellitus (NDM) are now more frequently reported (4). GDM poses significant dangers not only for the mother but also for the developing fetus (5). Unlike the common forms of diabetes, the causes and associated complications of GDM and NDM are not yet completely understood. However, diabetes may also be associated with metabolic syndromes (MetS), a medical term used for a combination of diabetes, high blood pressure (hypertension), and obesity (6). Diabetes also creates a greater risk for coronary heart disease, stroke, and other conditions affecting blood vessels, and notably in pregnancy, a relationship has been established between maternal MetS, GDM, and pregnancy outcomes (7). The current Research Topic aimed to collect studies reporting advancements in clinical and basic research related to GDM, NDM, and associated metabolic disorders. After a rigorous process of selection and review, the current volume presents an authoritative collection of 20 research articles exploring new dimensions in this topic.Firstly, introducing major players in metabolic disorders, Zhen et al. reviewed the role of kynurenic acid (KYNA) in the pathogenesis and development of several human endocrine and metabolic diseases. KYNA is a signaling molecule and a major player in metabolic diseases inclusive of diabetes and obesity. Their study promotes the notion that Frontiers in Endocrinology frontiersin.org 01

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