The kidneys are important organs similar in shape to beans located on both sides of the spine and their function is to filter water and toxic substances from the blood. The kidneys, like other members of the human body, are exposed to failure due to many factors that ultimately lead to kidney damage. About five millimeters of one hundred samples from dialysis patients were kept in test tubes designated for this purpose, where the samples were stored at appropriate temperature until the required number was completed, the same measures were also taken on the healthy group, which numbered fifty samples, and their ages were approximately equal to the ages of the dialysis patients. As for the results of the current research, it was proved that there was a significant increase in the levels of zonulin and the capacity of total antioxidants, urea, creatinine and glucose in dialysis patients compared to the control group. As for glutathione, there is no significant change.