No abstract

In this study, the effect of propofol on isolated bovine coronary artery tone was studied in artery rings precontracted with PGF2a. Propofol, in concentrations of 10-6-10-5 M did not change vascular smooth muscle tone, but at high concentrations (10-4-10-1 M) produced relaxation in rings with intact endothelium. In rings denuded of endothelium or treated with methylene blue, propofol produced relaxation at 10-3-10-1 M concentrations, but there was a significant decrease in relaxation compared to endothelium intact rings. In the presence of a calcium agonist (Bay K 8644; 10-5 M), propofol produced constriction in rings denuded of endothelium. These results suggest that high concentrations of propofol may have vasorelaxant effect on bovine coronary artery and that these effects may be due to actions on the endothelium and mediated by calcium channels.

In this study we aimed to investigate clinically whether morphine acts on the peripheral nervous system directly. Twenty adult patients, who were scheduled for upper extremity surgery under tourniquet, had intravenous regional anesthesia. They were divided into two groups: one group was given 30 ml of 1% prilocaine plus 10 ml of 0.9% sodium chloride (P group) and the other group was given 30 ml of 1% prilocaine plus 6 mg morphine sulfate in 10 ml of 0.9% sodium chloride (P/M group). The onset of analgesia and anesthesia and recovery from anesthesia and analgesia were investigated in both groups. In the P/M group, the onset of analgesia and anesthesia was statistically faster and the recovery from anesthesia and analgesia was statistically slower than in the P group (P < 0.05). We conclude that morphine is clinically effective in the peripheral nervous system at this dosage range.

The injury was performed with 600g-cm/weight on the spinal cord of 40 cats with T8-9 laminectomy in this study. Ten cats were given 10 mg/kg naloxone i.v. 1 h after injury. Ten cats were given 2 mg/kg thyrotropin-releasing hormone (TRH) i.v. l h after injury followed by lmg/kg per hour for 4 h. Intravenous lidocaine was begun 30 rain after injury in ten cats, administered as 1.5mg/kg over the initial 5min, 3mg/kg over the next 30 min and 1 mg/kg every 30 min for 4 h. The remaining ten cats were given only saline (control group). TRH-treated cats showed gignificantly better histopathological scores than either naloxone-or lidocaine-treated animals (KW: 13.65, P< 0.50).

This research was performed on fifteen patients to whom halothane anaesthesia was applied with intervals shorter than four weeks. ASA I and fi patients were premedicated with atropine sulphate 0.015 mglkg and dolantine 1 mg/kg intramuscularly, 45 minutes later 5 cc of blood sample was taken far the estimation of serum transaminase level (A1). After induction with the inhalation method (50% 02, 50% N20, 1-1.5% halothane), endotracheal intubation was pe,formed by giving succinylcholine 2 mg/kg 1.V. The maintenance of anaesthesia was assured with 33% 02, 66% N2O and 0.5-1 o/o halothane mixture in semiclosed system. At the end of the operation, 5 cc of blood sample was taken again (A11). Halothane anaesthesia was repeated for surgical reasons after three weeks. The same anaesthetic method was applied and the blood samples were taken preoperatively and postoperatively (Bu-B11). Serum transaminase levels were determined. When ArA11 and BrB11 parameters were compared statistically, the differance was unimportant (P>0.05). And when ArBı and Au-B11 parameters were compared, an increase was observed, however, this was not important statistically. Far this reason, it was decided that repeated halothane anaesthesia in ehi/dren at short intervals should be applied carefully.