tion of amido and hydroxyl groups in model compounds so that the positions of these groups in the ground state 5 more closely resemble their positions in the transition state for lactonization.Perhaps the hydroxyamide 5 will be more susceptible than la to imidazole-catalyzed lactonization. The parent acid of 5 has been reported to lactonize ~3 X 101 234 times faster than hydroxymethylbenzoic acid.19 (19) D. R. Storm and D. E. Koshland, Jr., Proc. Nat. Acad. Set.

A computer model of a bulk liquid polymer was built to investigate the problem of local order. The model is made of C30 n-alkane molecules; it is not a lattice model, but it allows for a continuous variability of torsion angles and interchain distances, subject to realistic intra- and intermolecular potentials. Experimental x-ray scattering curves and radial distribution functions are well reproduced. Calculated properties like end-to-end distances, distribution of torsion angles, radial distribution functions, and chain direction correlation parameters, all indicate a random coil conformation and no tendency to form bundles of parallel chains.

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The 3-butyl-2-phenylbenziodolium cation has been synthesized by the low-temperature reaction of transchlorovinyliodoso dichloride and írons-l-lithio-2-o-lithiophenyl-l-phenyl-1-hexene. The iodonium ion underwent attack by nucleophiles (Cl-, I-, and CH30-) exclusively at the 2 position to give a mixture of cis-and irans-stilbenes. Reaction of the iodonium ion with water in the absence of oxygen gave 2-o-iodophenyl-l-phenyl-l-hexanone, which has been independently synthesized by hydrolysis of íroros-l-iodo-2-o-iodophenyl-l-phenyl-l-hexene.Reaction of the iodonium ion with oxygen in water gave 2-hydroperoxy-2-o-iodophenyl-l-phenyl-l-hexanone, which was thermally cleaved to benzoic acid and 1-o-iodophenyl-l-pentanone. The latter compound has been independently synthesized by addition of butylmagnesium chloride to o-iodobenzaldehyde followed by oxidation of the resulting alcohol with the Jones reagent. The -hydroperoxy ketone was reduced by sodium borohydride or sodium iodide to 2-hydroxy-2-o-iodophenyl-l-phenyl-l-hexanone, which was oxidatively cleaved with lead