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It is demonstrated that under almost physiological conditions the absorption of urea increases from healthy, to congested, to inflamed urinary bladders. The following absorption rates of urea for different kinds of urinary bladders per hour were found: healthy 6%, congested 43%, inflamed 76%, congested and inflamed 66%, with haemorrhagic cystitis 90%.

In order to examine the absorption of the normal urinary components of the bladder under almost physiological conditions, an experimental model with rabbits was developed. After several preliminary experiments the following method was chosen: (1) ligature of both the ureters and the urethra in order to stop the urine flow to and from the bladder, as otherwise the absorbed test substance circulates back to the bladder; (2) sounding of the bladder via the ureter for instillation and emptying of the bladder; (3) sounding of the ureters via proximal for collecting urine of the renal pelvis; (4) puncture of the aorta for periodical withdrawal of larger blood volumes.