One dimensional (1D) metal organic framework (MOF) micro/nanostructural arrays are highly promising candidates for their potential applications in energy related areas. These exceptional behaviors are mainly attributed to their combined properties. Herein, we have synthesized trimetallic zeolite imidazolate framework (ZIF) based fibrous material via a feasible wet chemical method followed by the reliable electrospinning (ES) method. The successful implantation of metals into the organic frameworks was ensured initially and then subjected as the electrocatalyst for the oxygen evolution reaction (OER) under alkaline medium. The newly developed material showed the lesser overpotential of 273 mV at 10 mA cm–2 current density. The observed Tafel slope value and charge transfer resistance (R ct) value were found to be lesser. In addition to that, the synthesized material possessed remarkable stability over 12 h. From the aforementioned values, there is a confirmation that the observed enhancement in the electrocatalytic activity was mainly associated with the morphology and the combined physicochemical properties.

The explorations of earth-abundant, noble metal-free, highly efficient electrocatalysts for water-splitting reactions have been considered as highly significant for imperishable energy production. Though the metal organic framework (MOF)-based materials are highly promising candidates in the area of material chemistry, the combined properties associated with MOFs and the one-dimensional (1D) fibrous matrix, which can lead to better electrocatalytic performance, have been less explored. Herein, we ascertain a fabrication method for ZIF-67 (zeolite imidazolate framework) nanofibers (NFs), Fe-ZIF NFs, and Fe-ZIF-67 NFs via the wet chemical combined electrospinning (ES) approach. The as-synthesized catalysts were utilized for the electrochemical reaction, which showed a high efficiency toward the oxygen evolution reaction (OER). Compared to other catalysts, the Fe-ZIF-67 NF catalyst showed a very less overpotential of 278 mV at a fixed current density of 10 mA cm–2. The obtained Tafel slope and R ct values are 77 mV dec–1 and 1.2 Ω, respectively. The post-X-ray photoelectron spectroscopy (XPS) analysis revealed the transformation of FeOOH during the OER study along with Co3+ states in mixed Fe-ZIF-67 NFs. In an alkaline electrolyzer, Fe-ZIF-67 NFs were utilized as the anode and a Pt wire as the cathode in 1 M KOH solution, which required a cell voltage of 1.68 V at 10 mA cm–2 current density with astonishing stability. Hence, this work should open a new path for the exploration of efficient non-noble metal catalysts for energy-related applications.

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The UV- Vis spectroscopy determines the band gap of calcium oxide nanoparticles and also the calcium oxide nanoparticles shows excellent antibacterial activity due to its degradation property.

The aim of this study is to construct 3D models of potential drug targets for the Bacterial Kidney Disease (BKD) causing pathogen Renibacterium salmoninarum. The bacterial pathogen Renibacterium salmoninarum was selected for homology modeling studies since there were no known protein structures of the organism reported in the NCBI database. The reported protein sequences were run through DrugBank to pick out drug-targets. Online databases and web tools such as PMDB, UniProt, Drug Bank, and SwissModel were employed in this analysis. An aggregate of 412 protein sequences were identified as potential drug targets and were retrieved from the UniProt. Homology models of the protein sequences were constructed using the SwissModel database for all 412 proteins. These were then refined through a protein blast and Ramachandran plot analysis. Out of the 412 constructed models, 143 models were of reliable quality. These were then submitted to the PMDB database for further reference. To demonstrate the application of these constructed models, protein-ligand docking analysis using Auto Dock Vina was performed. Among the antibiotics that were tested against their known drug targets, trimethoprim demonstrated significant potential for the inhibition of R. salmoninarum’s dihydrofolate reductase protein, with a binding energy of -9.06 Kcal/mol and with the formation of 3 hydrogen bonds. Therefore through protein-ligand docking studies and the construction of 3D models of protein drug targets, Trimethoprim is proposed as a solution to the Bacterial Kidney Disease (BKD) problem in salmonid fishes. Further in-vitro evidences are in demand to prove this hypothesis.