Five new methylsulfonylpropenamides were isolated from tains a 4-geranyloxy-substituted phenethylamine unit with a different Glycosmis species collected in Thailand. Four of terminal formyl group. Two additional amides, doisuthine (6) these derivatives contain 4-geranyloxy-3-hydroxy-substi-and methoxydoisuthine (7), exhibit the structures of N-methtuted phenethylamine moieties. Sakerine (1) has a simple ge-ylanthranilic acid amides with phenethylamine and p-methranyloxy side chain; sakerone (2), sakerol (3), and dihydro-oxyphenethylamine as amine components. A l l structures isosakerol (4) are characterized by different states of oxida-were elucidated by IR, UV, 'H-, I3C-, 2D-NMR spectroscopy, tion in the geranyloxy residue. Methylgerambullal (5) con-mass spectrometry, and CD spectroscopy.

Nanotechnology is a scientific movement that has the potential to transform the diagnosis and treatment of disease in the 21st century. The area of investigation is defined by the study, design, manipulation, manufacture, and control of materials or devices by physical or chemical means at resolutions on the order of one billionth of a meter. The potential for a wide range of clinical applications makes a basic understanding of nanotechnology important to physiatrists. This review presents an introduction to nanotechnology and discusses key developments in tissue engineering, drug delivery, imaging, diagnostics, surface texturing, and biointerfaces that could impact the practice of physiatry in the future.